A Pooled Analysis to Compare the Clinical Characteristics of Human Papillomavirus-positive and -Negative Cervical Precancers.
Adult
Early Detection of Cancer
/ methods
Female
Global Health
Humans
Meta-Analysis as Topic
Papillomaviridae
/ isolation & purification
Papillomavirus Infections
/ complications
Precancerous Conditions
/ diagnosis
Prognosis
Uterine Cervical Neoplasms
/ diagnosis
Uterine Cervical Dysplasia
/ diagnosis
Journal
Cancer prevention research (Philadelphia, Pa.)
ISSN: 1940-6215
Titre abrégé: Cancer Prev Res (Phila)
Pays: United States
ID NLM: 101479409
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
17
04
2020
revised:
16
06
2020
accepted:
02
07
2020
pubmed:
14
7
2020
medline:
5
10
2021
entrez:
14
7
2020
Statut:
ppublish
Résumé
Given that high-risk human papillomavirus (HPV) is the necessary cause of virtually all cervical cancer, the clinical meaning of HPV-negative cervical precancer is unknown. We, therefore, conducted a literature search in Ovid MEDLINE, PubMed Central, and Google Scholar to identify English-language studies in which (i) HPV-negative and -positive, histologically confirmed cervical intraepithelial neoplasia grade 2 or more severe diagnoses (CIN2+) were detected and (ii) summarized statistics or deidentified individual data were available to summarize proportions of biomarkers indicating risk of cancer. Nineteen studies including 3,089 (91.0%) HPV-positive and 307 (9.0%) HPV-negative CIN2+ were analyzed. HPV-positive CIN2+ (vs. HPV-negative CIN2+) was more likely to test positive for biomarkers linked to cancer risk: a study diagnosis of CIN3+ (vs. CIN2; 18 studies; 0.56 vs. 0.24;
Identifiants
pubmed: 32655005
pii: 1940-6207.CAPR-20-0182
doi: 10.1158/1940-6207.CAPR-20-0182
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
829-840Informations de copyright
©2020 American Association for Cancer Research.