Do Recipients of Genetically Related Donors Have Better Outcomes After Living Donor Liver Transplantation?
ACR, acute cellular rejection
CMV, cytomegalovirus
HLA, human leukocyte antigen
LDLT, living donor liver transplantation
acute rejection
chronic rejection
liver transplantation
living donor
survival
Journal
Journal of clinical and experimental hepatology
ISSN: 0973-6883
Titre abrégé: J Clin Exp Hepatol
Pays: India
ID NLM: 101574137
Informations de publication
Date de publication:
Historique:
received:
07
05
2019
accepted:
16
12
2019
entrez:
14
7
2020
pubmed:
14
7
2020
medline:
14
7
2020
Statut:
ppublish
Résumé
There are few data on genetic relation of the donor and outcomes in living donor liver transplantation (LDLT) recipients. We compared outcomes of LDLT between recipients of genetically related and unrelated donors in a large single-center series. The study included 1372 adult, ABO-compatible, primary LDLT recipients, who received a graft from either a first-degree relative (parent, sibling, son, or daughter; n = 756) or unrelated donor (spouse or relative of the spouse; n = 616). The mean age of the recipients with a related donor was 50.2 ± 10.8 years compared with 47.3 ± 9.3 years for recipients with unrelated donors ( Although chronic rejection was found to be more common in genetically unrelated donors, the patient survival after LDLT was similar.
Sections du résumé
BACKGROUND
BACKGROUND
There are few data on genetic relation of the donor and outcomes in living donor liver transplantation (LDLT) recipients. We compared outcomes of LDLT between recipients of genetically related and unrelated donors in a large single-center series.
METHODS
METHODS
The study included 1372 adult, ABO-compatible, primary LDLT recipients, who received a graft from either a first-degree relative (parent, sibling, son, or daughter; n = 756) or unrelated donor (spouse or relative of the spouse; n = 616).
RESULTS
RESULTS
The mean age of the recipients with a related donor was 50.2 ± 10.8 years compared with 47.3 ± 9.3 years for recipients with unrelated donors (
CONCLUSION
CONCLUSIONS
Although chronic rejection was found to be more common in genetically unrelated donors, the patient survival after LDLT was similar.
Identifiants
pubmed: 32655237
doi: 10.1016/j.jceh.2019.12.004
pii: S0973-6883(19)30291-9
pmc: PMC7335709
doi:
Types de publication
Journal Article
Langues
eng
Pagination
334-338Informations de copyright
© 2019 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
The authors have none to declare.
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