DNA Methylation and Bladder Cancer: Where Genotype does not Predict Phenotype.
Bladder cancer
DNA methylation
cancer biomarkers
epigenetic
genotype
phenotype
Journal
Current genomics
ISSN: 1389-2029
Titre abrégé: Curr Genomics
Pays: United Arab Emirates
ID NLM: 100960527
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
17
05
2019
revised:
12
12
2019
accepted:
12
12
2019
entrez:
14
7
2020
pubmed:
14
7
2020
medline:
14
7
2020
Statut:
ppublish
Résumé
Nearly three decades ago, the association between Bladder cancer (BC) and DNA methylation has initially been reported. Indeed, in the recent years, the mechanism connecting these two has gained deeper insights. Still, the mediocre performance of DNA methylation markers in the clinics raises the major concern. Strikingly, whether it is the inter-individual methylation variations or the paucity of knowledge about methylation fingerprints lying within histologically distinct subtypes of BC requires critical discussion. In the future, besides identifying the initial causative factors, it will be important to illustrate the cascade of events that determines the fraction of the genome to convey altered methylation patterns specific towards each cancer type.
Identifiants
pubmed: 32655296
doi: 10.2174/1389202921666200102163422
pii: CG-21-34
pmc: PMC7324896
doi:
Types de publication
Journal Article
Langues
eng
Pagination
34-36Informations de copyright
© 2020 Bentham Science Publishers.
Références
Clin Exp Immunol. 2018 Oct;194(1):39-53
pubmed: 30009527
Dis Model Mech. 2018 Nov 16;11(11):
pubmed: 30459183
Clin Epigenetics. 2018 May 30;10:71
pubmed: 29854012
EBioMedicine. 2016 Jun;8:30-39
pubmed: 27428416
BMC Cancer. 2013 Jun 04;13:275
pubmed: 23735005
Cancers (Basel). 2019 Oct 19;11(10):
pubmed: 31635116
Eur Urol. 2017 Jan;71(1):96-108
pubmed: 27370177
J Urol. 1989 Jul;142(1):146-9
pubmed: 2733094
Eur Urol. 2013 Feb;63(2):234-41
pubmed: 22877502
Clin Cancer Res. 2002 Feb;8(2):464-70
pubmed: 11839665
Cancer Genet. 2019 Jun;235-236:18-20
pubmed: 31296310
Cancer Epidemiol Biomarkers Prev. 2018 Jun;27(6):689-695
pubmed: 29540343
Mol Cancer Ther. 2010 May;9(5):1443-50
pubmed: 20442312
Clin Genet. 2018 May;93(5):952-961
pubmed: 28902406
Cancer Treat Rev. 2017 Dec;61:82-93
pubmed: 29121502
Sci Rep. 2019 Dec 5;9(1):18464
pubmed: 31804560
Cancer Res. 1998 Jan 1;58(1):95-101
pubmed: 9426064