Expression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice.
atherosclerosis
chitotriosidase
collagen
hyaluronic acid
macrophage
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
03
2020
accepted:
29
05
2020
entrez:
14
7
2020
pubmed:
14
7
2020
medline:
14
7
2020
Statut:
epublish
Résumé
To determine whether overexpression of the chitin degrading enzyme, chitotriosidase (CHIT1), modulates macrophage function and ameliorates atherosclerosis. Using a mouse model that conditionally overexpresses CHIT1 in macrophages (CHIT1-Tg) crossbred with the These data demonstrate that CHIT1 alters cytokine expression and signaling pathways of classically activated macrophages.
Identifiants
pubmed: 32655419
doi: 10.3389/fphys.2020.00714
pmc: PMC7324766
doi:
Types de publication
Journal Article
Langues
eng
Pagination
714Subventions
Organisme : NHLBI NIH HHS
ID : F31 HL139082
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD007601
Pays : United States
Informations de copyright
Copyright © 2020 Yap, McCurdy, Alcala, Irei, Garo, Regan, Lee, Kitamoto and Boisvert.
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