Coronaviruses and Central Nervous System Manifestations.

COVID-19 SARS-CoV-2 brain disorders coronaviral infections neurological & psychiatric symptoms neurological infection and inflammation

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2020
Historique:
received: 18 04 2020
accepted: 11 06 2020
entrez: 14 7 2020
pubmed: 14 7 2020
medline: 14 7 2020
Statut: epublish

Résumé

SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most prominent symptoms of SARS-CoV-2 infection are respiratory. However, accumulating evidence highlights involvement of the central nervous system (CNS). This includes headache, anosmia, meningoencephalitis, acute ischemic stroke, and several presumably post/para-infectious syndromes and altered mental status not explained by respiratory etiologies. Interestingly, previous studies in animal models emphasized the neurotropism of coronaviruses; thus, these CNS manifestations of COVID-19 are not surprising. This minireview scans the literature regarding the involvement of the CNS in coronavirus infections in general, and in regard to the recent SARS-CoV-2, specifically.

Identifiants

pubmed: 32655490
doi: 10.3389/fneur.2020.00715
pmc: PMC7324719
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

715

Informations de copyright

Copyright © 2020 Khateb, Bosak and Muqary.

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Auteurs

Mohamed Khateb (M)

Department of Neurology, Rambam Health Care Campus, Haifa, Israel.

Noam Bosak (N)

Department of Neurology, Rambam Health Care Campus, Haifa, Israel.

Maryam Muqary (M)

Department of Psychiatry, Rambam Health Care Campus, Haifa, Israel.

Classifications MeSH