JAK inhibitors and infections risk: focus on herpes zoster.
AK
JAK inhibitors
herpes zoster
immune-mediated diseases
inflammatory arthritis
rheumatoid arthritis
Journal
Therapeutic advances in musculoskeletal disease
ISSN: 1759-720X
Titre abrégé: Ther Adv Musculoskelet Dis
Pays: England
ID NLM: 101517322
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
11
2019
accepted:
27
05
2020
entrez:
14
7
2020
pubmed:
14
7
2020
medline:
14
7
2020
Statut:
epublish
Résumé
Currently, there is a growing interest in Janus kinase (JAK) intracellular signalling since targeted inhibitors against these pathways are proving effective in the treatment of a range of immune-mediated diseases, such as rheumatoid arthritis (RA), psoriasis, psoriatic arthritis (PsA), inflammatory bowel disease and atopic dermatitis. In particular, post marketing experience and the increasing development of new pharmacological inhibitors of broad and increasingly selective JAK pathways provide new insights into the JAK pathway role in viral infections as well as their pathogenic role in immune-mediated inflammatory diseases. Herein we provide an overview of the biological role of JAK signalling and its role in immunity against viruses, with particular regard to herpes zoster reactivation. Thereafter, we will discuss the evidence currently available on the principal JAK inhibitors and their association with viral infections.
Identifiants
pubmed: 32655703
doi: 10.1177/1759720X20936059
pii: 10.1177_1759720X20936059
pmc: PMC7328488
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1759720X20936059Informations de copyright
© The Author(s), 2020.
Déclaration de conflit d'intérêts
Conflict of interest statement: FS: nothing to disclose. IBM has received honoraria or research funding from Abbvie, Lilly, Pfizer, BMS, UCB and Celgene. SS has received honoraria or research funding from Abbvie, Pfizer, Janssen, BMS, UCB, Celgene, Boehringer Ingelheim and Novartis
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