Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases.
Aging
/ drug effects
Animals
Anti-Inflammatory Agents
/ chemistry
Cardiovascular Physiological Phenomena
/ drug effects
Cellular Senescence
/ drug effects
Diabetes Mellitus
/ metabolism
Flavonoids
/ chemistry
Humans
Neuroprotection
/ drug effects
Obesity
/ metabolism
Osteoporosis
/ drug therapy
Psoralea
/ chemistry
Signal Transduction
/ drug effects
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
02
2020
revised:
12
05
2020
accepted:
28
05
2020
entrez:
14
7
2020
pubmed:
14
7
2020
medline:
6
5
2021
Statut:
epublish
Résumé
During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to "inflammaging," which is a state of chronic, systemic, sterility, low-grade inflammatory microenvironment and a key risk factor in the development of aging-related diseases. Fructus psoraleae is a traditional Chinese medical herb best known for delaying aging and treating osteoporosis. Prenylflavonoids from fructus psoraleae are the main bioactive compounds responsible for its pharmacological applications, such as beaching, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone. In previous decades, there have been some promising studies on the pharmacology of fructus psoraleae. Here, we focus on the anti-inflammatory and antiaging diseases of five psoralea prenylflavonoids, such as cardiovascular protection, diabetes and obesity intervention, neuroprotection, and osteoporosis, and discuss the mechanism of these active ingredients for better understanding the material basis and drug application of fructus psoraleae in Chinese medicine.
Identifiants
pubmed: 32655760
doi: 10.1155/2020/2128513
pmc: PMC7320294
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Flavonoids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2128513Informations de copyright
Copyright © 2020 Yi-Ting Zhou et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Thromb Res. 2015 Dec;136(6):1310-7
pubmed: 26553017
Yao Xue Xue Bao. 2006 Jan;41(1):76-9
pubmed: 16683532
Oxid Med Cell Longev. 2015;2015:732596
pubmed: 26583062
CNS Neurosci Ther. 2020 Apr 28;:
pubmed: 32343048
J Bone Miner Res. 2016 Nov;31(11):1920-1929
pubmed: 27341653
Immunity. 2014 Oct 16;41(4):518-28
pubmed: 25367569
Phytomedicine. 2018 Jan 1;38:166-174
pubmed: 29425649
Brain Res. 2011 Mar 25;1382:315-20
pubmed: 21276430
Acta Pharmacol Sin. 2019 Apr;40(4):425-440
pubmed: 30382185
J Neurochem. 2006 Apr;97(2):435-48
pubmed: 16539667
J Biol Chem. 2001 Mar 23;276(12):8836-40
pubmed: 11121427
Phytomedicine. 2014 Mar 15;21(4):400-5
pubmed: 24220018
Acta Pharm Sin B. 2020 Mar;10(3):462-474
pubmed: 32140392
FEBS Lett. 2013 Sep 17;587(18):2930-5
pubmed: 23907009
Phytomedicine. 2010 Feb;17(2):126-31
pubmed: 19577453
Evid Based Complement Alternat Med. 2015;2015:920431
pubmed: 26199639
Am J Physiol Regul Integr Comp Physiol. 2012 May 15;302(10):R1184-90
pubmed: 22461176
Phytother Res. 2019 Jul;33(7):1851-1864
pubmed: 31119811
Eur J Pharmacol. 2012 Sep 15;691(1-3):28-37
pubmed: 22760073
Free Radic Biol Med. 2011 May 15;50(10):1382-91
pubmed: 21382476
J Biol Chem. 2005 Apr 8;280(14):13720-7
pubmed: 15644335
Diabetes. 2006 Jan;55(1):120-7
pubmed: 16380484
Ageing Res Rev. 2019 Sep;54:100942
pubmed: 31415806
Ageing Res Rev. 2018 Sep;46:14-31
pubmed: 29742452
J Bone Miner Res. 2012 Nov;27(11):2344-58
pubmed: 22729939
Nat Med. 2017 Sep;23(9):1072-1079
pubmed: 28825716
Circulation. 2012 Mar 6;125(9):1122-33
pubmed: 22302838
J Pharmacol Sci. 2019 Feb;139(2):105-111
pubmed: 30642751
EMBO J. 2009 Mar 18;28(6):686-96
pubmed: 19197242
Nature. 2013 Apr 11;496(7444):238-42
pubmed: 23535595
J Mol Neurosci. 2013 Feb;49(2):369-79
pubmed: 23001813
Exp Neurol. 2012 Jun;235(2):528-38
pubmed: 22417924
Br J Pharmacol. 2011 Sep;164(2):332-43
pubmed: 21410687
Eur J Pharmacol. 2019 Apr 5;848:49-54
pubmed: 30690005
Molecules. 2018 Mar 08;23(3):
pubmed: 29518051
J Alzheimers Dis. 2015;45(2):407-21
pubmed: 25790933
PLoS One. 2017 Jan 6;12(1):e0169560
pubmed: 28060896
Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1789-95
pubmed: 18599796
J Neurosci. 2010 Apr 21;30(16):5525-32
pubmed: 20410106
Phytother Res. 2019 Feb;33(2):403-411
pubmed: 30421466
J Bone Miner Res. 1998 Sep;13(9):1370-7
pubmed: 9738508
Obes Rev. 2019 May;20(5):701-712
pubmed: 30828970
JCI Insight. 2017 Sep 7;2(17):
pubmed: 28878136
Mediators Inflamm. 2018 Apr 17;2018:9076485
pubmed: 29849499
Biochem Pharmacol. 2018 Jun;152:338-346
pubmed: 29660314
PLoS One. 2013 Jul 19;8(7):e69019
pubmed: 23904909
Evid Based Complement Alternat Med. 2014;2014:958937
pubmed: 24829606
Fitoterapia. 2015 Mar;101:99-106
pubmed: 25596095
Nutrients. 2016 Feb 06;8(2):83
pubmed: 26861390
Int J Mol Sci. 2018 Jun 06;19(6):
pubmed: 29882838
Biochem Biophys Res Commun. 2016 Aug 5;476(4):574-579
pubmed: 27261434
Food Chem Toxicol. 2019 Mar;125:133-140
pubmed: 30597224
Biochem Pharmacol. 2008 Jun 1;75(11):2175-82
pubmed: 18433733
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2933-8
pubmed: 19196989
Int Immunopharmacol. 2013 Jan;15(1):38-41
pubmed: 23164691
Antioxid Redox Signal. 2017 Jan 1;26(1):28-43
pubmed: 27308893
Behav Brain Res. 2018 Jan 15;336:32-39
pubmed: 28851669
Biochem Biophys Res Commun. 2019 Sep 3;516(4):1229-1233
pubmed: 31300199
FEBS Lett. 2008 Feb 6;582(3):451-6
pubmed: 18201570
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14960-5
pubmed: 8962164
PPAR Res. 2015;2015:549691
pubmed: 26713087
J Immunol. 2018 Jan 15;200(2):749-757
pubmed: 29246953
Bone. 2019 Jun;123:265-273
pubmed: 30946971
Diabetologia. 2016 Jun;59(6):1276-86
pubmed: 26983922
J Gerontol A Biol Sci Med Sci. 2013 Jul;68(7):780-92
pubmed: 23213032
J Agric Food Chem. 2011 Mar 9;59(5):1697-704
pubmed: 21309574
Neuroscience. 2007 May 25;146(3):1245-58
pubmed: 17363174
Molecules. 2011 May 03;16(5):3701-12
pubmed: 21540797
Blood. 2004 Feb 1;103(3):921-6
pubmed: 14525788
Atherosclerosis. 2015 Nov;243(1):107-19
pubmed: 26363808
Brain Res. 2006 Jun 22;1096(1):196-203
pubmed: 16725118
Cardiovasc Res. 2010 May 1;86(2):236-42
pubmed: 20164116
Mol Cell Endocrinol. 2015 Dec 5;417:103-13
pubmed: 26419930
Arch Pharm Res. 2008 Nov;31(11):1419-23
pubmed: 19023538
J Neurochem. 2012 Jan;120(1):115-24
pubmed: 22004348
Biol Pharm Bull. 2015;38(8):1199-207
pubmed: 26235583
Clin Chim Acta. 2013 Sep 23;424:245-52
pubmed: 23782937
Cell Stem Cell. 2011 Aug 5;9(2):131-43
pubmed: 21816364
Biomed Chromatogr. 2017 Dec;31(12):
pubmed: 28618051
Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1632-41
pubmed: 22539595
Free Radic Biol Med. 2019 Apr;134:702-707
pubmed: 30654017
Evid Based Complement Alternat Med. 2019 Nov 7;2019:2160175
pubmed: 31781261
Eur Heart J. 2007 Aug;28(15):1805-13
pubmed: 17412728
Aging (Albany NY). 2019 Sep 5;11(17):6941-6950
pubmed: 31484803
Circ Res. 2009 Feb 27;104(4):496-505
pubmed: 19131647
Toxicol Appl Pharmacol. 2015 Nov 15;289(1):70-8
pubmed: 26348140
Arterioscler Thromb Vasc Biol. 2018 May;38(5):1134-1146
pubmed: 29545239
Nat Commun. 2016 May 23;7:11624
pubmed: 27211851
Small. 2020 Jan;16(1):e1905977
pubmed: 31814281
Brain Res. 2013 Jul 3;1520:168-77
pubmed: 23688544
Transl Stroke Res. 2015 Feb;6(1):50-9
pubmed: 25085436
J Nat Prod. 1996 Jul;59(7):671-2
pubmed: 8759164
Front Physiol. 2015 Mar 24;6:85
pubmed: 25852572
Evid Based Complement Alternat Med. 2015;2015:852194
pubmed: 26557867
Ageing Res Rev. 2016 Mar;26:81-95
pubmed: 26732035
J Steroid Biochem Mol Biol. 2015 Jul;151:102-7
pubmed: 25218443
Molecules. 2018 Jan 04;23(1):
pubmed: 29300354
Biol Pharm Bull. 2005 Dec;28(12):2253-7
pubmed: 16327160
J Cereb Blood Flow Metab. 2017 Mar;37(3):1120-1136
pubmed: 27339263
Eur J Pharmacol. 2010 Jun 25;636(1-3):181-8
pubmed: 20361957
Int J Mol Sci. 2016 Apr 08;17(4):527
pubmed: 27070585
Mol Neurobiol. 2018 Apr;55(4):3290-3299
pubmed: 28488208
Food Chem Toxicol. 2020 Feb;136:111027
pubmed: 31870919
Oxid Med Cell Longev. 2018 Mar 25;2018:8678267
pubmed: 29765506
Diabetes Care. 2006 Sep;29(9):2039-45
pubmed: 16936150
Bone. 2015 Oct;79:242-51
pubmed: 26103094
Br J Pharmacol. 2018 Aug;175(16):3298-3314
pubmed: 29570770
Phytomedicine. 2020 Jul 15;73:152808
pubmed: 30935723
Cell Metab. 2015 Jan 6;21(1):65-80
pubmed: 25565206
J Cell Physiol. 2019 Aug;234(10):17212-17231
pubmed: 30916407
Hypertension. 2018 Jul;72(1):227-234
pubmed: 29735632
Bioorg Med Chem Lett. 2015 Jun 15;25(12):2579-83
pubmed: 25978962
Rejuvenation Res. 2011 Feb;14(1):25-31
pubmed: 21204649
Stroke. 2003 Aug;34(8):1981-6
pubmed: 12829864
J Biol Chem. 2005 Oct 21;280(42):35209-16
pubmed: 16109714
Br J Pharmacol. 2008 May;154(1):226-33
pubmed: 18332857
Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7829-34
pubmed: 10869427
Phytomedicine. 2019 Jun;59:152785
pubmed: 31009850
Molecules. 2016 Aug 17;21(8):
pubmed: 27548120
Neuroscience. 2011 May 5;181:292-9
pubmed: 21376106
Pharm Biol. 2017 Dec;55(1):2136-2144
pubmed: 28982307
Thromb Res. 2019 Jul;179:64-68
pubmed: 31082751
FASEB J. 2019 Nov;33(11):12929-12940
pubmed: 31490085
Pharmacology. 2015;95(3-4):105-10
pubmed: 25766656
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10659-64
pubmed: 12130665
Aging (Albany NY). 2019 Dec 26;11(24):12361-12374
pubmed: 31881005
Oxid Med Cell Longev. 2019 Dec 26;2019:4310319
pubmed: 31976027
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3324-9
pubmed: 15728361
Oncotarget. 2017 Sep 16;8(49):86188-86205
pubmed: 29156787
Oxid Med Cell Longev. 2019 Nov 21;2019:1862437
pubmed: 31871541
Nat Rev Immunol. 2017 Dec;17(12):774-785
pubmed: 28972206
Eur J Pharmacol. 2015 May 5;754:11-8
pubmed: 25704611
Brain Res. 2006 Jan 12;1068(1):221-9
pubmed: 16368081
J Neurosci. 2000 Jan 15;20(2):558-67
pubmed: 10632585
Planta Med. 2012 Jun;78(9):903-6
pubmed: 22573369
Phytomedicine. 2012 Apr 15;19(6):551-61
pubmed: 22397994
Phytother Res. 2017 Aug;31(8):1265-1272
pubmed: 28639266
Mol Neurobiol. 2019 Nov;56(11):7267-7283
pubmed: 31016475
Aging Dis. 2018 Aug 1;9(4):605-622
pubmed: 30090650
J Neurosci Res. 2019 Jun;97(6):645-660
pubmed: 30600840
J Clin Invest. 2008 Nov;118(11):3775-89
pubmed: 18846253