Adult-Onset Still's Disease: Typical Presentation, Delayed Diagnosis.
adult-onset still’s disease
arthritis
fever
rash
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
08 Jun 2020
08 Jun 2020
Historique:
entrez:
14
7
2020
pubmed:
14
7
2020
medline:
14
7
2020
Statut:
epublish
Résumé
Adult-onset Still's disease (AOSD) is an uncommon auto-inflammatory disease of unknown etiology, with a classical triad of fever, arthritis, and evanescent rash. Its low prevalence and lack of specific guidelines contribute to frequent delays in diagnosis and treatment. Clinical manifestations vary greatly between mainly systemic or articular symptoms and the clinical pattern between monocyclic, polycyclic, or chronic illness. Treatment options include non-steroid anti-inflammatory drugs (NSAIDs), systemic corticoids, disease-modifying anti-rheumatic drugs (DMARDs), and, more recently, biological agents directed at identified immune pathological pathways like anti-interleukin-1 (IL-1) or anti-tumor necrosis factor-alpha (TNF-alpha). We report a case of a 40-year-old male with persistent fever, polyarthralgia, sore throat, and rash for two weeks despite antibiotic treatment for suspected bacterial pharyngitis. During hospitalization and after extensive diagnostic workup, an AOSD diagnosis was made according to Yamaguchi's criteria and successfully managed with systemic corticoids.
Identifiants
pubmed: 32656026
doi: 10.7759/cureus.8510
pmc: PMC7346332
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e8510Informations de copyright
Copyright © 2020, Seco et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Med Chir Trans. 1897;80:47-60.9
pubmed: 20896907
Rev Med Chil. 2009 Aug;137(8):1010-6
pubmed: 19915763
J Rheumatol. 1992 Mar;19(3):424-30
pubmed: 1578458
J Rheumatol. 2001 Feb;28(2):322-9
pubmed: 11246670
Ann Rheum Dis. 1988 Sep;47(9):764-7
pubmed: 3178317
J Dermatol. 2008 Feb;35(2):106-10
pubmed: 18271807
Ann Rheum Dis. 1971 Mar;30(2):121-33
pubmed: 5315135
Mod Rheumatol. 2018 Sep;28(5):736-757
pubmed: 29651907
Ann Rheum Dis. 1995 Jul;54(7):587-90
pubmed: 7668903
Medicine (Baltimore). 2005 Nov;84(6):331-7
pubmed: 16267408
Clin Exp Rheumatol. 2000 Mar-Apr;18(2):245-8
pubmed: 10812499
Ther Clin Risk Manag. 2014 Dec 22;11:33-43
pubmed: 25653531
Rheumatology (Oxford). 2001 Dec;40(12):1398-404
pubmed: 11752512