Sulfonylurea-Induced Hypoglycemia in a Patient With Cirrhosis.
drug contraindications
liver cirrhosis
sulfonylurea compounds
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
08 Jun 2020
08 Jun 2020
Historique:
entrez:
14
7
2020
pubmed:
14
7
2020
medline:
14
7
2020
Statut:
epublish
Résumé
Type 2 diabetes mellitus is highly prevalent among patients with cirrhosis. The pharmacological management of this disease in patients with chronic liver disease remains controversial, however. Insulin secretagogues such as sulfonylureas are associated with a high risk of hypoglycemia among diabetics. In patients with cirrhosis, this risk is more pronounced due to decreased hepatic clearance, concurrent alcoholism, hypoalbuminemia, and acute liver decompensation. In this case report, we present a case of severe refractory hypoglycemia secondary to glipizide in a patient with alcoholic cirrhosis. We believe that the use of sulfonylureas in this patient population should be contraindicated to avoid debilitating neurologic damage and death following hypoglycemia.
Identifiants
pubmed: 32656029
doi: 10.7759/cureus.8513
pmc: PMC7346303
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e8513Informations de copyright
Copyright © 2020, Braet et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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