Can X-Ray Powder Diffraction Be a Suitable Forensic Method for Illicit Drug Identification?
Raman spectroscopy
X-ray powder diffraction
drug detection
infrared spectroscopy
new psychoactive substances
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
03
2020
accepted:
14
05
2020
entrez:
14
7
2020
pubmed:
14
7
2020
medline:
14
7
2020
Statut:
epublish
Résumé
New psychoactive substances (NPSs) are associated with a significant number of intoxications. With the number of readily available forms of these drugs rising every year, there are even risks for the general public. Consequently, there is a high demand for methods sufficiently sensitive to detect NPSs in samples found at the crime scene. Infrared (IR) and Raman spectroscopies are commonly used for such detection, but they have limitations; for example, fluorescence in Raman can overlay the signal and when the sample is a mixture sometimes neither Raman nor IR is able to identify the compounds. Here, we investigate the potential of X-ray powder diffraction (XRPD) to analyse samples seized on the black market. A series of psychoactive substances (heroin, cocaine, mephedrone, ephylone, butylone, JWH-073, and naphyrone) was measured. Comparison of their diffraction patterns with those of the respective standards showed that XRPD was able to identify each of the substances. The same samples were analyzed using IR and Raman, which in both cases were not able to detect the compounds in all of the samples. These results suggest that XRPD could be a valuable addition to the range of forensic tools used to detect these compounds in illicit drug samples.
Identifiants
pubmed: 32656182
doi: 10.3389/fchem.2020.00499
pmc: PMC7325198
doi:
Types de publication
Journal Article
Langues
eng
Pagination
499Informations de copyright
Copyright © 2020 Jurásek, Bartůněk, Huber, Fagan, Setnička, Králík, Dehaen, Svozil and Kuchař.
Références
AAPS J. 2017 May;19(3):736-742
pubmed: 28091881
J Chem Inf Model. 2019 Aug 26;59(8):3400-3412
pubmed: 31361490
J Anal Toxicol. 2015 Jul-Aug;39(6):426-35
pubmed: 25957385
Anal Chim Acta. 2012 Jan 20;711:1-6
pubmed: 22152788
Forensic Sci Int. 2018 Jul;288:227-235
pubmed: 29777946
Forensic Sci Int. 2019 Sep;302:109911
pubmed: 31563026
J Pharm Sci. 2000 Nov;89(11):1432-42
pubmed: 11015688
Drug Test Anal. 2019 Jun;11(6):833-846
pubmed: 30610761
Drug Test Anal. 2018 Feb;10(2):372-378
pubmed: 28544816
Talanta. 2019 Apr 1;195:414-418
pubmed: 30625563
Talanta. 2018 Aug 15;186:427-432
pubmed: 29784383
J Forensic Sci. 2015 Sep;60(5):1171-81
pubmed: 26175160
J Forensic Sci. 1975 Apr;20(2):348-72
pubmed: 164513
J Hazard Mater. 2013 Oct 15;261:628-36
pubmed: 23995559
J Hazard Mater. 2015 Jan 23;282:18-25
pubmed: 25062553
RSC Adv. 2018 May 1;8(29):16243-16250
pubmed: 35542213
Drug Test Anal. 2016 Aug;8(8):847-57
pubmed: 26344849
Anal Bioanal Chem. 2017 Oct;409(25):5821-5836
pubmed: 28634759
J Anal Toxicol. 2017 Jun 1;41(5):376-381
pubmed: 28334805
J Pharm Biomed Anal. 2018 Feb 5;149:494-501
pubmed: 29175556
Analyst. 2016 Feb 7;141(3):902-9
pubmed: 26779571
J Hazard Mater. 2016 Oct 5;316:134-42
pubmed: 27232724
Anal Bioanal Chem. 2016 May;408(13):3571-91
pubmed: 27071765
Clin Chem. 2018 Aug;64(8):1221-1229
pubmed: 29776952
J Hazard Mater. 2020 Feb 15;384:121306
pubmed: 31622847
Drug Test Anal. 2019 May;11(5):697-708
pubmed: 30394697
Forensic Toxicol. 2015;33(2):175-194
pubmed: 26257831
J Anal Toxicol. 2020 Apr 30;44(3):298-300
pubmed: 31776572
Curr Neuropharmacol. 2017;15(5):663-681
pubmed: 27834146