Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer.

Breast cancer Prognostic markers Tumour immunology

Journal

NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891

Informations de publication

Date de publication:
2020
Historique:
received: 27 05 2019
accepted: 02 06 2020
entrez: 14 7 2020
pubmed: 14 7 2020
medline: 14 7 2020
Statut: epublish

Résumé

The extent and composition of the immune response in a breast cancer is one important prognostic factor for the disease. The aim of the current work was to refine the analysis of the humoral component of an immune response in breast tumors by quantifying mRNA expression of different immunoglobulin classes and study their association with prognosis. We used RNA-Seq data from two local population-based breast cancer cohorts to determine the expression of

Identifiants

pubmed: 32656317
doi: 10.1038/s41523-020-0170-2
pii: 170
pmc: PMC7338507
doi:

Types de publication

Journal Article

Langues

eng

Pagination

28

Informations de copyright

© The Author(s) 2020.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare that they have no competing interests.

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Auteurs

Christer Larsson (C)

Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden.

Anna Ehinger (A)

Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Sofia Winslow (S)

Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden.

Karin Leandersson (K)

Cancer Immunology, Department of Translational Medicine, Lund University, Malmö, Sweden.

Marie Klintman (M)

Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Ludvig Dahl (L)

Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Johan Vallon-Christersson (J)

Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Jari Häkkinen (J)

Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Cecilia Hegardt (C)

Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Jonas Manjer (J)

Surgery, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

Lao Saal (L)

Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Lisa Rydén (L)

Surgery, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Martin Malmberg (M)

Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Åke Borg (Å)

Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Niklas Loman (N)

Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Classifications MeSH