A comparison of thyroidal protection by stable iodine or perchlorate in the case of acute or prolonged radioiodine exposure.
Iodine blockade
Medical NRBC protection
Nuclear and radiological emergency
Perchlorate
Radioiodine
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
20
04
2020
accepted:
15
06
2020
pubmed:
14
7
2020
medline:
17
6
2021
entrez:
14
7
2020
Statut:
ppublish
Résumé
In the case of a nuclear power plant accident, repetitive/prolonged radioiodine release may occur. Radioiodine accumulates in the thyroid and by irradiation enhances the risk of cancer. Large doses of non-radioactive iodine may protect the thyroid by inhibiting radioiodine uptake into the gland (iodine blockade). Protection is based on a competition at the active carrier site in the cellular membrane and the Wolff-Chaikoff effect, the latter being, however, only transient (24-48 h). Perchlorate may alternatively provide protection by a carrier competition mechanism only. Perchlorate has, however, a stronger affinity to the carrier than iodide. Based on an established biokinetic-dosimetric model developed to study iodine blockade, and after its extension to describe perchlorate pharmacokinetics and the inhibition of iodine transport through the carrier, we computed the protective efficacies that can be achieved by stable iodine or perchlorate in the case of an acute or prolonged radioiodine exposure. In the case of acute radioiodine exposure, perchlorate is less potent than stable iodine considering its ED
Identifiants
pubmed: 32656655
doi: 10.1007/s00204-020-02809-z
pii: 10.1007/s00204-020-02809-z
pmc: PMC7415763
doi:
Substances chimiques
Iodine Radioisotopes
0
Perchlorates
0
Radiation-Protective Agents
0
Iodine
9679TC07X4
perchlorate
VLA4NZX2P4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3231-3247Références
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