TWIRLS, a knowledge-mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2.
coronavirus
cytokine storm
literature mining
renin-angiotensin system
topic inference
Journal
Drug development research
ISSN: 1098-2299
Titre abrégé: Drug Dev Res
Pays: United States
ID NLM: 8204468
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
revised:
05
06
2020
received:
15
04
2020
accepted:
27
06
2020
medline:
14
7
2020
pubmed:
14
7
2020
entrez:
14
7
2020
Statut:
ppublish
Résumé
Faced with the current large-scale public health emergency, collecting, sorting, and analyzing biomedical information related to the "SARS-CoV-2" should be done as quickly as possible to gain a global perspective, which is a basic requirement for strengthening epidemic control capacity. However, for human researchers studying viruses and hosts, the vast amount of information available cannot be processed effectively and in a timely manner, particularly if our scientific understanding is also limited, which further lowers the information processing efficiency. We present TWIRLS (Topic-wise inference engine of massive biomedical literatures), a method that can deal with various scientific problems, such as liver cancer, acute myeloid leukemia, and so forth, which can automatically acquire, organize, and classify information. Additionally, this information can be combined with independent functional data sources to build an inference system via a machine-based approach, which can provide relevant knowledge to help human researchers quickly establish subject cognition and to make more effective decisions. Using TWIRLS, we automatically analyzed more than three million words in more than 14,000 literature articles in only 4 hr. We found that an important regulatory factor angiotensin-converting enzyme 2 (ACE2) may be involved in host pathological changes on binding to the coronavirus after infection. On triggering functional changes in ACE2/AT2R, the cytokine homeostasis regulation axis becomes imbalanced via the Renin-Angiotensin System and IP-10, leading to a cytokine storm. Through a preliminary analysis of blood indices of COVID-19 patients with a history of hypertension, we found that non-ARB (Angiotensin II receptor blockers) users had more symptoms of severe illness than ARB users. This suggests ARBs could potentially be used to treat acute lung injury caused by coronavirus infection.
Identifiants
pubmed: 32657473
doi: 10.1002/ddr.21717
pmc: PMC7404951
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1004-1018Subventions
Organisme : Chongqing Health Commission COVID-19 Project
ID : 2020NCPZX01
Organisme : PLA Youth Talent Project
ID : 17QNP010
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020 The Authors. Drug Development Research published by Wiley Periodicals, LLC.
Références
Amini-Bavil-Olyaee, S., Choi, Y. J., Lee, J. H., Shi, M., Huang, I.-C., Farzan, M., & Jung, J. U. (2013). The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry. Cell Host & Microbe, 13(4), 452-464.
Benter, I. F., Yousif, M. H., Anim, J., Cojocel, C., & Diz, D. (2006). Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME. American Journal of Physiology. Heart and Circulatory Physiology, 290(2), H684-H691.
Boehm, M., & Nabel, E. G. (2002). Angiotensin-converting enzyme 2-a new cardiac regulator. New England Journal of Medicine, 347(22), 1795-1797.
Brasier, A. R., Ron, D., Tate, J. E., & Habener, J. F. (1990). A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element. The EMBO Journal, 9(12), 3933-3944.
Chan, J. F.-W., Yuan, S., Kok, K.-H., To KK-W, Chu, H., Yang, J., … Poon, R. W.-S. (2020). A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster. The Lancet, 395, 514-523.
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., … Wei, Y. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. The Lancet, 395, 507-513.
Cook, H., & Jensen, L. J. (2019). A Guide to Dictionary-Based Text Mining. Methods of Molecular Biology, 73-89.
Corvol, P., Eyries, M., & Soubrier, F. (2004). Peptidyl-dipeptidase A/angiotensin I-converting enzyme. In Handbook of proteolytic enzymes (pp. 332-346). Academic Press: Elsevier.
Corvol, P., & Jeunemaitre, X. (1997). Molecular genetics of human hypertension: Role of angiotensinogen. Endocrine Reviews, 18(5), 662-677.
Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., … Jeyaseelan, R. (2000). A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circulation Research, 87(5), e1-e9.
El Bekay, R., Alvarez, M., Monteseirín, J., Alba, G., Chacón, P., Vega, A., … Bedoya, F. J. (2003). Oxidative stress is a critical mediator of the angiotensin II signal in human neutrophils: Involvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-κB. Blood, 102(2), 662-671.
Grobe, J. L., Mecca, A. P., Mao, H., & Katovich, M. J. (2006). Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension. American Journal of Physiology. Heart and Circulatory Physiology, 290(6), H2417-H2423.
Gurwitz, D. (2020). Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. Drug Development Research, 1-4.
Hein, L., Barsh, G. S., Pratt, R. E., Dzau, V. J., & Kobilka, B. K. (1995). Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice. Nature, 377(6551), 744-747.
Henrion, D. (2012). Why do we need a selective angiotensin II type 2 receptor agonist? Hypertension, 60(3), 616-617.
Hettne, K. M., Williams, A. J., van Mulligen, E. M., Kleinjans, J., Tkachenko, V., & Kors, J. A. (2010). Automatic vs. manual curation of a multi-source chemical dictionary: The impact on text mining. Journal of Cheminformatics, 2(1), 1-7.
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., … Gu, X. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395, 497-506.
Ide, N., Hirase, T., Nishimoto-Hazuku, A., Ikeda, Y., & Node, K. (2008). Angiotensin II increases expression of IP-10 and the renin-angiotensin system in endothelial cells. Hypertension Research, 31(6), 1257-1267.
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., … Leong-Poi, H. (2005). Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature, 436(7047), 112-116.
Jia, H. (2016). Pulmonary angiotensin-converting enzyme 2 (ACE2) and inflammatory lung disease. Shock, 46(3), 239-248.
Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., … Deng, W. (2005). A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nature Medicine, 11(8), 875-879.
Magaldi, A. J., Cesar, K. R., de Araújo, M., e Silva, A. C. S., & Santos, R. A. (2003). Angiotensin-(1-7) stimulates water transport in rat inner medullary collecting duct: Evidence for involvement of vasopressin V 2 receptors. Pflügers Archiv, 447(2), 223-230.
Nataraj, C., Oliverio, M. I., Mannon, R. B., Mannon, P. J., Audoly, L. P., Amuchastegui, C. S., … Coffman, T. M. (1999). Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. The Journal of Clinical Investigation, 104(12), 1693-1701.
Pan, F., Ye, T., Sun, P., Gui, S., Liang, B., Li, L., … Yang, L. (2020). Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia. Radiology, 200370.
Reimand, J., Isserlin, R., Voisin, V., Kucera, M., Tannuslopes, C., Rostamianfar, A., … Xu, C. (2019). Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap. Nature Protocols, 14(2), 482-517.
Rothlin, R. P., Vetulli, H. M., Duarte, M., & Pelorosso, F. G. (2020). Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID. Drug Development Research, (1).1-3.
Rudemiller, N. P., & Crowley, S. D. (2016). Interactions between the immune and the renin-angiotensin systems in hypertension. Hypertension, 68(2), 289-296.
Ruiz-Ortega, M., Ruperez, M., Lorenzo, O., Esteban, V., Blanco, J., Mezzano, S., & Egido, J. (2002). Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney. Kidney International, 62, S12-S22.
Shah, A., Oh, Y.-B., Lee, S. H., Lim, J. M., & Kim, S. H. (2012). Angiotensin-(1-7) attenuates hypertension in exercise-trained renal hypertensive rats. American Journal of Physiology. Heart and Circulatory Physiology, 302(11), H2372-H2380.
Skeggs, L., Dorer, F., Levine, M., Lentz, K., & Kahn, J. (1980). The biochemistry of the renin-angiotensin system. Advances in Experimental Medicine and Biology, 130, 1-27.
Soto-Pantoja, D. R., Menon, J., Gallagher, P. E., & Tallant, E. A. (2009). Angiotensin-(1-7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor. Molecular Cancer Therapeutics, 8(6), 1676-1683.
Sriram, K., & Insel, P. A. (2020). Dangers of ACE inhibitor and ARB usage in COVID-19: Evaluating the evidence. medRxiv, 1-12.
Sriramula, S., Haque, M., Majid, D. S., & Francis, J. (2008). Involvement of tumor necrosis factor-α in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy. Hypertension, 51(5), 1345-1351.
Sugaya, T., Nishimatsu, S.-i., Tanimoto, K., Takimoto, E., Yamagishi, T., Imamura, K., … Otsuka, A. (1995). Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. Journal of Biological Chemistry, 270(32), 18719-18722.
Suzuki, Y., Ruiz-Ortega, M., Gomez-Guerrero, C., Tomino, Y., & Egido, J. (2003). Angiotensin II, the immune system and renal diseases: Another road for RAS? Nephrology, Dialysis, Transplantation, 18(8), 1423-1426.
Wan S, Yi Q, Fan S, Lv J, Zhang X, Guo L, Lang C, Xiao Q, Xiao K, Yi Z. 2020. Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients with 2019 novel coronavirus pneumonia (NCP). medRxiv.
Wei Z, Rong-Hui D, Bei L, Xiao-Shuang Z, Xing-Lou Y, Ben H, Yan-Yi W, Geng-Fu X, Bing Y, Zheng-Li S and others. 2020. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.
World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: Interim guidance. pp. 21-21; 2020. https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf. opens in new tab).
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., … McLellan, J. S. (2020). Cryo-EM structure of the 2019-nCoV spike in the Prefusion conformation. Science, 367, 1260-1263.
Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., … Zhu, L. (2020). Pathological findings of COVID-19 associated with acute respiratory distress syndrome. The Lancet Respiratory Medicine, 8(4), 420-422.
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., … Huang, C.-L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270-273).
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., … Lu, R. (2020). A novel coronavirus from patients with pneumonia in China. New England Journal of Medicine, 382, 727-733.