Glial cell activation and altered metabolic profile in the spinal-trigeminal axis in a rat model of multiple sclerosis associated with the development of trigeminal sensitization.
Astrocytes
Experimental autoimmune encephalomyelitis
Metabolomics
Microglia
Satellite glial cells
Trigeminal pain
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
22
03
2020
revised:
19
06
2020
accepted:
03
07
2020
pubmed:
14
7
2020
medline:
28
4
2021
entrez:
14
7
2020
Statut:
ppublish
Résumé
Trigeminal neuralgia is often an early symptom of multiple sclerosis (MS), and it generally does not correlate with the severity of the disease. Thus, whether it is triggered simply by demyelination in specific central nervous system areas is currently questioned. Our aims were to monitor the development of spontaneous trigeminal pain in an animal model of MS, and to analyze: i) glial cells, namely astrocytes and microglia in the central nervous system and satellite glial cells in the trigeminal ganglion, and ii) metabolic changes in the trigeminal system. The subcutaneous injection of recombinant MOG
Identifiants
pubmed: 32659316
pii: S0889-1591(20)30385-8
doi: 10.1016/j.bbi.2020.07.001
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
268-280Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.