Diminished expression of 5hmc in Reed-Sternberg cells in classical Hodgkin lymphoma is a common epigenetic marker.
Classical Hodgkin lymphoma
Epigenetics
Methylation
vitamin C
Journal
Leukemia research
ISSN: 1873-5835
Titre abrégé: Leuk Res
Pays: England
ID NLM: 7706787
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
13
02
2019
revised:
28
04
2020
accepted:
28
06
2020
pubmed:
14
7
2020
medline:
15
12
2020
entrez:
14
7
2020
Statut:
ppublish
Résumé
Loss of the epigenetic marker 5-hydroxymethylcytosine (5hmC) has been demonstrated in a variety of neoplasms. Several recent studies have shown epigenetic alteration in Classical Hodgkin lymphoma (CHL), which may impact treatment. We demonstrate near universal depletion of 5hmC in the neoplastic Hodgkin Reed-Sternberg (H/RS) cells in all cases of CHL (49/49). We hypothesized that the addition of vitamin C-a cofactor for the ten-eleven translocation (TET) enzymes which oxidize 5-methylcytosine (5mC) to 5hmC - may replenish levels of 5hmC. The CHL cell line L428 was grown in optimal conditions and then subjected to vitamin C treatment, which demonstrated reduced cell viability as well as caspase activation and increased concentration of 5hmC. A more detailed understanding of the epigenetic landscape of CHL may help guide future therapies.
Identifiants
pubmed: 32659407
pii: S0145-2126(20)30113-2
doi: 10.1016/j.leukres.2020.106408
pii:
doi:
Substances chimiques
Biomarkers
0
5-hydroxymethylcytosine
1123-95-1
5-Methylcytosine
6R795CQT4H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106408Informations de copyright
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