High levels of boron promote anchorage-independent growth of nontumorigenic cells.

Boron Cell Line Cell Transformation, Neoplastic Epithelial Cells Humans Phosphatidylinositol 3-Kinases
Boron Tumorigenic pathway Tumorigenic risk Well drinking water

Journal

Environmental pollution (Barking, Essex : 1987)
ISSN: 1873-6424
Titre abrégé: Environ Pollut
Pays: England
ID NLM: 8804476

Informations de publication

Date de publication:
Nov 2020
Historique:
received: 03 03 2020
revised: 22 06 2020
accepted: 22 06 2020
pubmed: 14 7 2020
medline: 17 9 2020
entrez: 14 7 2020
Statut: ppublish

Résumé

WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells.

Identifiants

DOI: 10.1016/j.envpol.2020.115094 PMID: 32659568
pubmed: 32659568
pii: S0269-7491(20)31587-6
doi: 10.1016/j.envpol.2020.115094
pii:
doi:

Substances chimiques

Boron N9E3X5056Q

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115094

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest All authors declare that they have no competing interests.

Auteurs

Huadong Xu (H)

Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Voluntary Body for International Health Care in Universities, Nagoya, Japan.

Kazunori Hashimoto (K)

Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Voluntary Body for International Health Care in Universities, Nagoya, Japan.

Masao Maeda (M)

Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Mohammad Daud Azimi (MD)

Human Resources of Ministry of Public Health, Kabul, Afghanistan.

Said Hafizullah Fayaz (SH)

Department of Healthcare Administration, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Administrative Office of the President, Deputy Public Relations and Outreach, Kabul, Afghanistan.

Wei Chen (W)

Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Voluntary Body for International Health Care in Universities, Nagoya, Japan.

Nobuyuki Hamajima (N)

Department of Healthcare Administration, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Masashi Kato (M)

Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan; Voluntary Body for International Health Care in Universities, Nagoya, Japan; Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Matsumoto-cho, Kasugai-shi, Aichi, Japan. Electronic address: katomsasa@med.nagoya-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Métalloïdes › Bore › High levels of boron promote...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › High levels of boron promote...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › High levels of boron promote...
questionsmedicales.fr › Cellules › Cellules épithéliales › High levels of boron promote...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › High levels of boron promote...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › High levels of boron promote...