The Regulatory Role of IL-10 in Neurodegenerative Diseases.
IL-10
microglia
neurodegeneration
neuroinflammation
signaling
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
09 07 2020
09 07 2020
Historique:
received:
29
05
2020
revised:
01
07
2020
accepted:
07
07
2020
entrez:
15
7
2020
pubmed:
15
7
2020
medline:
17
4
2021
Statut:
epublish
Résumé
IL-10, an immunosuppressive cytokine, is considered an important anti-inflammatory modulator of glial activation, preventing inflammation-mediated neuronal degeneration under pathological conditions. In this narrative review, we summarize recent insights about the role of IL-10 in the neurodegeneration associated with neuroinflammation, in diseases such as Multiple Sclerosis, Traumatic Brain Injury, Amyotrophic lateral sclerosis, Alzheimer's Disease, and Parkinson's Disease, focusing on the contribution of this cytokine not only in terms of protective action, but also as possibly responsible for clinical worsening. The knowledge of this double face of the same coin, regarding the biological role of the IL-10, could aid the development of targeted therapies useful for limiting neurodegenerative processes.
Identifiants
pubmed: 32659950
pii: biom10071017
doi: 10.3390/biom10071017
pmc: PMC7407888
pii:
doi:
Substances chimiques
IL10 protein, human
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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