Immunohistochemical detection of p53 and pp53 Ser
Cell proliferation
Dog
Hemangiomas
Hemangiosarcomas
Ki-67
Phospho-p53 Serine392
Skin
p53
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
13 Jul 2020
13 Jul 2020
Historique:
received:
21
09
2019
accepted:
06
07
2020
entrez:
15
7
2020
pubmed:
15
7
2020
medline:
9
3
2021
Statut:
epublish
Résumé
p53 protein is essential for the regulation of cell proliferation. Aberrant accumulation of it usually occurs in cutaneous malignancies. Mutant p53 is detected by immunohistochemistry because it is more stable than the wild-type p53. However, post-translational modifications of p53 in response to ultraviolet radiation are important mechanisms of wild-type p53 stabilization, leading to positive staining in the absence of mutation. The aims were: 1) to analyze the immunohistochemical expression of p53 and phospho-p53 Serine p53 and phospho-p53 Serine The p53 and phospho-p53 Serine
Sections du résumé
BACKGROUND
BACKGROUND
p53 protein is essential for the regulation of cell proliferation. Aberrant accumulation of it usually occurs in cutaneous malignancies. Mutant p53 is detected by immunohistochemistry because it is more stable than the wild-type p53. However, post-translational modifications of p53 in response to ultraviolet radiation are important mechanisms of wild-type p53 stabilization, leading to positive staining in the absence of mutation. The aims were: 1) to analyze the immunohistochemical expression of p53 and phospho-p53 Serine
RESULTS
RESULTS
p53 and phospho-p53 Serine
CONCLUSIONS
CONCLUSIONS
The p53 and phospho-p53 Serine
Identifiants
pubmed: 32660487
doi: 10.1186/s12917-020-02457-6
pii: 10.1186/s12917-020-02457-6
pmc: PMC7359283
doi:
Substances chimiques
Ki-67 Antigen
0
Tumor Suppressor Protein p53
0
Tumor Suppressor Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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