The PRDM14-CtBP1/2-PRC2 complex regulates transcriptional repression during the transition from primed to naïve pluripotency.
Embryonic stem cells
PRDM14–CtBP1/2–PRC2 complex
Pluripotency
Transcriptional repression
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
14 08 2020
14 08 2020
Historique:
received:
27
11
2019
accepted:
25
06
2020
pubmed:
15
7
2020
medline:
22
6
2021
entrez:
15
7
2020
Statut:
epublish
Résumé
The pluripotency-associated transcriptional network is regulated by a core circuitry of transcription factors. The PR domain-containing protein PRDM14 maintains pluripotency by activating and repressing transcription in a target gene-dependent manner. However, the mechanisms underlying dichotomic switching of PRDM14-mediated transcriptional control remain elusive. Here, we identified C-terminal binding protein 1 and 2 (CtBP1 and CtBP2; generically referred to as CtBP1/2) as components of the PRDM14-mediated repressive complex. CtBP1/2 binding to PRDM14 depends on CBFA2T2, a core component of the PRDM14 complex. The loss of
Identifiants
pubmed: 32661086
pii: jcs.240176
doi: 10.1242/jcs.240176
pii:
doi:
Substances chimiques
Co-Repressor Proteins
0
DNA-Binding Proteins
0
PRDM14 protein, human
0
RNA-Binding Proteins
0
Transcription Factors
0
Alcohol Oxidoreductases
EC 1.1.-
CTBP2 protein, human
EC 1.1.-
Polycomb Repressive Complex 2
EC 2.1.1.43
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.