Behavior-related gene regulatory networks: A new level of organization in the brain.
behavior
development
network
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
22 09 2020
22 09 2020
Historique:
pubmed:
15
7
2020
medline:
11
11
2020
entrez:
15
7
2020
Statut:
ppublish
Résumé
Neuronal networks are the standard heuristic model today for describing brain activity associated with animal behavior. Recent studies have revealed an extensive role for a completely distinct layer of networked activities in the brain-the gene regulatory network (GRN)-that orchestrates expression levels of hundreds to thousands of genes in a behavior-related manner. We examine emerging insights into the relationships between these two types of networks and discuss their interplay in spatial as well as temporal dimensions, across multiple scales of organization. We discuss properties expected of behavior-related GRNs by drawing inspiration from the rich literature on GRNs related to animal development, comparing and contrasting these two broad classes of GRNs as they relate to their respective phenotypic manifestations. Developmental GRNs also represent a third layer of network biology, playing out over a third timescale, which is believed to play a crucial mediatory role between neuronal networks and behavioral GRNs. We end with a special emphasis on social behavior, discuss whether unique GRN organization and
Identifiants
pubmed: 32661177
pii: 1921625117
doi: 10.1073/pnas.1921625117
pmc: PMC7519311
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
23270-23279Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM114341
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131819
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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