Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.

Adipose Tissue / drug effects Animals Antibodies, Monoclonal Cachexia / complications Cell Line, Tumor Crystallography, X-Ray Glial Cell Line-Derived Neurotrophic Factor Receptors / genetics Growth Differentiation Factor 15 / genetics Heterografts Humans Lipid Peroxidation Mice Multiprotein Complexes / genetics Muscle, Skeletal / drug effects Neoplasms / complications Proto-Oncogene Mas Proto-Oncogene Proteins c-ret / genetics Signal Transduction Weight Loss

Journal

Nature medicine

ISSN: 1546-170X

Titre abrégé: Nat Med

Pays: United States

ID NLM: 9502015

Informations de publication

Date de publication:
08 2020

Historique:

received: 27 01 2020

accepted: 20 05 2020

pubmed: 15 7 2020

medline: 29 10 2020

entrez: 15 7 2020

Statut: ppublish

Résumé

Cancer cachexia is a highly prevalent condition associated with poor quality of life and reduced survival

Identifiants

DOI: 10.1038/s41591-020-0945-x PMID: 32661391

pubmed: 32661391

doi: 10.1038/s41591-020-0945-x

pii: 10.1038/s41591-020-0945-x

doi:

Substances chimiques

Antibodies, Monoclonal 0

Glial Cell Line-Derived Neurotrophic Factor Receptors 0

Growth Differentiation Factor 15 0

MAS1 protein, human 0

Multiprotein Complexes 0

Proto-Oncogene Mas 0

Proto-Oncogene Proteins c-ret EC 2.7.10.1

RET protein, human EC 2.7.10.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

1264-1270

Commentaires et corrections

Type : CommentIn

Références

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