Association of Polychlorinated Biphenyls and Organochlorine Pesticides with Autism Spectrum Disorder in Jamaican Children.
Autism Spectrum Disorder (ASD)
Interaction
Jamaica
Organochlorine (OC) pesticides
Polychlorinated biphenyls (PCBs)
glutathione S-transferase (GST) genes
Journal
Research in autism spectrum disorders
ISSN: 1750-9467
Titre abrégé: Res Autism Spectr Disord
Pays: Netherlands
ID NLM: 101300021
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
entrez:
15
7
2020
pubmed:
15
7
2020
medline:
15
7
2020
Statut:
ppublish
Résumé
Polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides are suspected to play a role in autism spectrum disorder (ASD). To investigate associations of PCBs and OC pesticides with ASD in Jamaican children and explore possible interaction between PCBs or OC pesticides with glutathione Participants included n=169 age- and sex-matched case-control pairs of Jamaican children 2-8 years old. Socioeconomic status and food frequency data were self-reported by the parents/guardians. Blood from each participant was analyzed for 100 PCB congeners and 17 OC pesticides and genotyped for three GST genes. PCBs and OC pesticides concentrations below the limit of detection (LoD) were replaced with (LoD/√2). We used conditional logistic regression (CLR) models to assess associations of PCBs and OC pesticides with ASD, individually or interactively with GST genes ( We found inverse associations of PCB-153 [adjusted MOR (95% CI) = 0.44 (0.23-0.86)] and PCB-180 [adjusted MOR (95% CI) = 0.52 (0.28-0.95)] with ASD. When adjusted for covariates in a CLR the interaction between Differences in diet between ASD and typically developing control groups may play a role in the observed findings of lower concentrations of PCB-153 and PCB-180 in individuals with ASD than in controls. Considering the limited sample size and high proportion of concentrations below the LoD, these results should be interpreted with caution but warrant further investigation into associations of PCBs and OC pesticides with ASD.
Sections du résumé
BACKGROUND
BACKGROUND
Polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides are suspected to play a role in autism spectrum disorder (ASD).
OBJECTIVES
OBJECTIVE
To investigate associations of PCBs and OC pesticides with ASD in Jamaican children and explore possible interaction between PCBs or OC pesticides with glutathione
METHODS
METHODS
Participants included n=169 age- and sex-matched case-control pairs of Jamaican children 2-8 years old. Socioeconomic status and food frequency data were self-reported by the parents/guardians. Blood from each participant was analyzed for 100 PCB congeners and 17 OC pesticides and genotyped for three GST genes. PCBs and OC pesticides concentrations below the limit of detection (LoD) were replaced with (LoD/√2). We used conditional logistic regression (CLR) models to assess associations of PCBs and OC pesticides with ASD, individually or interactively with GST genes (
RESULTS
RESULTS
We found inverse associations of PCB-153 [adjusted MOR (95% CI) = 0.44 (0.23-0.86)] and PCB-180 [adjusted MOR (95% CI) = 0.52 (0.28-0.95)] with ASD. When adjusted for covariates in a CLR the interaction between
DISCUSSION
CONCLUSIONS
Differences in diet between ASD and typically developing control groups may play a role in the observed findings of lower concentrations of PCB-153 and PCB-180 in individuals with ASD than in controls. Considering the limited sample size and high proportion of concentrations below the LoD, these results should be interpreted with caution but warrant further investigation into associations of PCBs and OC pesticides with ASD.
Identifiants
pubmed: 32661462
doi: 10.1016/j.rasd.2020.101587
pmc: PMC7357892
mid: NIHMS1605402
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES022165
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD057808
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003167
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024148
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES027801
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000371
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest The authors declare no conflict of interest.
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