Alpha-lipoic acid prevents brain injury in rats administered with valproic acid.
alpha-lipoic acid
brain
enzymes
oxidative stress
valproic acid
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
12
03
2020
revised:
21
05
2020
accepted:
30
06
2020
pubmed:
15
7
2020
medline:
24
6
2021
entrez:
15
7
2020
Statut:
ppublish
Résumé
Valproic acid (VPA) is an effective drug, which is preferred for the treatments of epilepsy and various kinds of seizures. Nonetheless, VPA has many life-threatening side effects associated with free radical production. Alpha-lipoic acid (ALA) is a powerful antioxidant, which can scavenge reactive oxygen species (ROS). The effects of ALA against VPA-stimulated brain injury were investigated. In this study, Sprague-Dawley rats were divided as four groups: Group I, control rats; Group II, ALA-administered rats (50 mg/kg/d); Group III, VPA-administered rats (0.5 g/kg/d); Group IV: VPA- and ALA-administered rats at the same dose and time. According to the results, VPA increased lipid peroxidation, protein carbonyl, advanced oxidation protein products, total oxidant status, nitric oxide levels and glutathione-S-transferase, adenosine deaminase, xanthine oxidase activities, decreased glutathione, total antioxidant capacity levels, catalase, superoxide dismutase, glutathione peroxidase, sodium-potassium ATPase, and paraoxonase activities. Treatment with ALA reversed these effects. In conclusion, we may suggest that ALA may be a good candidate for prevention of VPA-induced brain injury.
Substances chimiques
Antioxidants
0
Valproic Acid
614OI1Z5WI
Thioctic Acid
73Y7P0K73Y
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22580Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
T. Tomson, D. Battino, E. Perucca, Lancet Neurol. 2016, 15, 210.
C. L. Bowden, Bipolar Disord. 2003, 5, 189.
J. Fu, C. J. Shao, F. R. Chen, H. K. Ng, Z. P. Chen, Neuro Oncol. 2010, 12, 328.
B. B. Sokmen, S. Tunali, R. Yanardag, Food Chem. Toxicol. 2012, 50, 3562.
S. Oktay, B. Alev, S. Tunali, E. Emekli-Alturfan, T. Tunali-Akbay, L. Koc-Ozturk, R. Yanardag, A. Yarat, Hum. Exp. Toxicol. 2015, 34, 654.
S. Tunali, S. Kahraman, R. Yanardag, Hum. Exp. Toxicol. 2015, 34, 904.
U. V. Ustundag, S. Tunali, B. Alev, H. Ipekci, E. Emekli-Altırfan, T. Tunali Akbay, R. Yanardag, A. Yarat, J. Food Biochem. 2016, 40, 132.
S. Gezginci-Oktayoglu, I. B. Turkyilmaz, M. Ercin, R. Yanardag, S. Bolkent, Protoplasma 2016, 253, 127.
E. W. Y. Tung, L. M. Winn, Mol. Pharmacol. 2011, 80, 979.
F. T. Rosa, M. A. Zulet, J. S. Marchini, J. A. Martinez, Int. J. Food Sci. Nutr. 2012, 63, 749.
G. C. G. Militao, P. M. P. Ferreira, R. M. de Freitas, Neurochem. Int. 2010, 56, 16.
A. O. Abdel-Zaher, R. H. Abdel-Hady, W. M. Abdel Moneim, S. Y. Salim, Exp. Toxicol. Pathol. 2011, 63, 161.
H. Z. Toklu, T. Hakan, N. Biber, S. Solakoğlu, A. V. Oğünç, G. Sener, Free Radic. Res. 2009, 43, 658.
R. M. Freitas, Neurosci. Lett. 2009, 455, 140.
J. Perera, J. H. Tan, S. Jeevathayaparan, S. Chakravarthi, N. Haleagrahara, Cell Biosci. 2011, 1, 12. https://doi.org/10.1186/2045-3701-1-12
H. Elsawy, M. A. Al-Omaira, A. Sedkyc, L. Al-Otaibid, J. Chem. Neuroanat. 2017, 86, 52.
H. M. Saleh, Y. S. El-Sayed, S. M. Naser, A. S. Eltahawy, A. Onoda, M. Umezawa, Environ. Sci. Pollut. Res. Int. 2017, 24, 24593.
P. Arivazhagan, T. Thilakavathy, K. Ramanathan, S. Kumaran, C. Pannerselvam, J. Nutr. Biochem. 2002, 13, 619.
T. Diken Allahverdi, E. Allahverdi, S. Yayla, T. Deprem, O. Merhan, S. Vural, B. Sülü, Y. Günerhan, N. Köksal, Ulus. Travma Acil Cerrahi Derg. 2015, 21, 9.
E. Beutler, Glutathione in Red Cell Metabolism a Manual of Biochemical Methods, 2nd ed., Grune and Stratton, New York 1975, pp. 112-114.
A. Ledwozyw, J. Michalak, A. Stepien, A. Kadziołka, Clin. Chim. Acta 1986, 155, 275.
H. Aebi, Methods Enzymol. 1984, 105, 121.
A. A. Mylroie, A. H. Collins, C. Umbles, J. Kyle, Toxicol. Appl. Pharmacol. 1986, 82, 512.
D. E. Paglia, W. N. Valentine, J. Lab. Clin. Med. 1967, 70, 158.
A. Wendel, Methods Enzymol. 1981, 77, 325.
W. H. Habig, W. B. Jacoby, Methods Enzymol. 1981, 77, 398.
A. S. Ridderstap, S. L. Bonting, Am. J. Physiol. 1969, 217, 1721 1721.
C. E. Furlong, R. J. Richter, S. L. Seidel, A. G. Motulsky, Am. J. Hum. Genet. 1988, 43, 230.
H. Karker, Scand. J. Clin. Lab. Invest. 1964, 16, 570.
E. D. Corte, F. Stirpe, Biochem. J. 1968, 108, 349.
R. L. Levine, D. Garland, C. N. Oliver, A. Amici, I. Climent, A. G. Lenz, Methods Enzymol. 1990, 186, 464.
V. Witko-Sarsat, M. Friedlander, C. Capeillère-Blandin, T. Nguyen-Khoa, A. T. Nguyen, J. Zingraff, P. Jungers, B. Descamps-Latscha, Kidney Int. 1996, 49, 1304.
O. Erel, Clin. Biochem. 2004, 37, 277.
O. Erel, Clin. Biochem. 2005, 38, 1103.
K. M. Miranda, M. G. Espey, D. A. Wink, Nitric Oxide 2001, 5, 62.
O. H. Lowry, H. J. Rosebrough, A. L. Fall, R. J. Randall, J. Biol. Chem. 1951, 193, 265.
I. Jafarian, M. R. Eskandari, V. Mashayekhi, M. Ahadpour, M. J. Hosseini, Toxicol. Mech. Methods 2013, 23, 617.
W. Wei, H. Wang, Y. Wu, K. Ding, T. Li, Z. Cong, J. Xu, M. Zhou, L. Huang, H. Ding, H. Wu, Neurochem. Int. 2015, 87, 85.
T. Q. Oliveria, C. N. S. de Sousa, G. S. Vasconcelosa, L. C. de Soussa, A. A. de Oliveira, C. F. V. Patrocinio, I. D. S. Medeirosa, J. E. R. Honorio Júnior, M. Maes, D. Macedo, S. M. M. Vasconcelos, J. Affect Disord. 2017, 219, 49.
H. Zhao, M. Bu, B. Li, Y. Zhang, Tissue Cell 2018, 50, 37.
M. Smeyne, R. J. Smeyne, Free Radic. Biol. Med. 2013, 62, 13.
H. G. Hegazy, E. H. A. Ali, A. H. M. Elgoly, Cytokine 2015, 71, 173.
G. M. Ourique, E. M. Saccol, T. S. Pês, W. G. Glanzner, S. H. Schiefelbein, V. M. Woehl, B. Baldisserotto, M. A. Pavanato, P. B. Gonçalves, K. P. Barreto, Food Chem. Toxicol. 2016, 95, 159.
D. Tibullo, G. Li Volti, C. Giallongo, S. Grasso, D. Tomassoni, C. D. Anfuso, G. Lupo, F. Amenta, T. Avola, V. Bramanti, Inflamm. Res. 2017, 66, 947.
Y. Zhang, C. Yang, G. Yuan, Z. Wang, W. Cui, R. Li, Inflamm. Res. 2015, 35, 263.
S. Tunali, Hum. Exp. Toxicol. 2014, 33, 623.
E. Emekli-Alturfan, B. Alev, S. Tunali, S. Oktay, T. Tunali-Akbay, L. K. Ozturk, R. Yanardag, A. Yarat, Ann. Clin. Lab. Sci. 2015, 45, 166.
A. Göder, G. Nagel, A. Kraus, B. Dörsam, N. Seiwert, B. Kaina, J. Fahrer, Carcinogenesis 2015, 36, 817.
F. Aydin, E. B. Kalaz, C. Kucukgergin, J. Coban, S. Dogru-Abbasoglu, M. Uysal, Curr. Aging Sci. 2018, 11, 10.
K. Gulati, N. Rai, A. Ray, Vitam. Horm. 2017, 103, 169.
S. Blanco, R. Hernández, G. Franchelli, M. M. Ramos-Álvarez, M. A. Peinado, Nitric Oxide 2017, 62, 32.
R. Heidari, F. Jafari, F. Khodaei, B. S. Yeganeh, H. Niknahadi, Nephrology 2018, 23, 351.
H. Kumar, B. Sharma, Brain Res. 2016, 1630, 83.
S. Chaudhary, S. Parvez, Arch. Med. Res. 2018, 49, 441.