Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
10 09 2020
10 09 2020
Historique:
pubmed:
15
7
2020
medline:
15
12
2020
entrez:
15
7
2020
Statut:
ppublish
Résumé
Visceral leishmaniasis (VL) is a parasitic infection that results in approximately 26 000-65 000 deaths annually. The available treatments are hampered by issues such as toxicity, variable efficacy, and unsuitable dosing options. The need for new treatments is urgent and led to a collaboration between the Drugs for Neglected Diseases
Identifiants
pubmed: 32663005
doi: 10.1021/acs.jmedchem.0c00705
pmc: PMC7748245
doi:
Substances chimiques
Antiprotozoal Agents
0
Naphthyridines
0
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9523-9539Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203134/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204672/Z/16/Z
Pays : United Kingdom
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