Naked mole-rats suppress energy metabolism and modulate membrane cholesterol in chronic hypoxia.
enzymes
hypoxia tolerance
membrane lipids
metabolic suppression
sodium/potassium ATPase
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
pubmed:
15
7
2020
medline:
6
10
2020
entrez:
15
7
2020
Statut:
ppublish
Résumé
Naked mole-rats (NMRs) are mammalian champions of hypoxia tolerance that enter metabolic suppression to survive in low oxygen environments. Common physiological mechanisms used by animals to suppress metabolic rate include downregulating energy metabolism (ATP supply) as well as ion pumps (primary cellular ATP consumers). A recent goldfish study demonstrated that remodeling of membrane lipids may mediate these responses, but it is unknown if NMR employs the same strategies; therefore, we aimed to test the hypotheses that these fossorial mammals
Identifiants
pubmed: 32663032
doi: 10.1152/ajpregu.00057.2020
pmc: PMC7473896
doi:
Substances chimiques
Cholesterol
97C5T2UQ7J
Sodium-Potassium-Exchanging ATPase
EC 7.2.2.13
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
R148-R155Références
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