The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles.
hippocampus
memory
neocortex
neural circuits
synaptic inhibition
synaptic plasticity
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
30
06
2020
received:
30
01
2020
accepted:
08
07
2020
pubmed:
15
7
2020
medline:
4
11
2021
entrez:
15
7
2020
Statut:
ppublish
Résumé
GABAergic interneurons are highly diverse, and their synaptic outputs express various forms of plasticity. Compelling evidence indicates that activity-dependent changes of inhibitory synaptic transmission play a significant role in regulating neural circuits critically involved in learning and memory and circuit refinement. Here, we provide an updated overview of inhibitory synaptic plasticity with a focus on the hippocampus and neocortex. To illustrate the diversity of inhibitory interneurons, we discuss the case of two highly divergent interneuron types, parvalbumin-expressing basket cells and neurogliaform cells, which support unique roles on circuit dynamics. We also present recent progress on the molecular mechanisms underlying long-term, activity-dependent plasticity of fast inhibitory transmission. Lastly, we discuss the role of inhibitory synaptic plasticity in neuronal circuits' function. The emerging picture is that inhibitory synaptic transmission in the CNS is extremely diverse, undergoes various mechanistically distinct forms of plasticity and contributes to a much more refined computational role than initially thought. Both the remarkable diversity of inhibitory interneurons and the various forms of plasticity expressed by GABAergic synapses provide an amazingly rich inhibitory repertoire that is central to a variety of complex neural circuit functions, including memory.
Identifiants
pubmed: 32663353
doi: 10.1111/ejn.14907
pmc: PMC9150441
mid: NIHMS1809032
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6882-6901Subventions
Organisme : NIMH NIH HHS
ID : R01 MH116673
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA017392
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC015234
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC013770
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC019827
Pays : United States
Organisme : NINDS NIH HHS
ID : UF1 NS115779
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS113600
Pays : United States
Informations de copyright
© 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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