Strategy for Determining the Free Fraction of Labile Covalent Modulators in Plasma Using Equilibrium Dialysis.

Blood Proteins / metabolism Dialysis Humans Pharmaceutical Preparations Plasma / metabolism Protein Binding Renal Dialysis
Covalent inhibitors Covalent modulators Drug-drug interactions Equilibrium dialysis Free fraction Labile compounds PPB Plasma protein binding Serum albumin Temperature effect on protein binding Unstable drugs α-acid glycoprotein

Journal

Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R

Informations de publication

Date de publication:
10 2020
Historique:
received: 16 01 2020
revised: 14 06 2020
accepted: 29 06 2020
pubmed: 15 7 2020
medline: 22 6 2021
entrez: 15 7 2020
Statut: ppublish

Résumé

Determination of free drug fraction (f

Identifiants

DOI: 10.1016/j.xphs.2020.06.029 PMID: 32663597
pubmed: 32663597
pii: S0022-3549(20)30363-4
doi: 10.1016/j.xphs.2020.06.029
pii:
doi:

Substances chimiques

Blood Proteins 0
Pharmaceutical Preparations 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3181-3189

Informations de copyright

Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Auteurs

Christian Leung (C)

Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080.

Jane R Kenny (JR)

Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080.

Cornelis E C A Hop (CECA)

Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080.

Zhengyin Yan (Z)

Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080. Electronic address: yanz7@gene.com.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Strategy for Determining the Free Fraction of...
questionsmedicales.fr › Phénomènes chimiques › Dialyse › Strategy for Determining the Free Fraction of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Strategy for Determining the Free Fraction of...
questionsmedicales.fr › Préparations pharmaceutiques › Strategy for Determining the Free Fraction of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Plasma sanguin › Strategy for Determining the Free Fraction of...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Strategy for Determining the Free Fraction of...
questionsmedicales.fr › Thérapeutique › Détoxication par sorption › Dialyse rénale › Strategy for Determining the Free Fraction of...