Application of "spider-web" mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule.
Animals
Anti-Inflammatory Agents, Non-Steroidal
/ pharmacology
Biomarkers, Pharmacological
/ analysis
Capsules
/ chemistry
Chalcone
/ analogs & derivatives
Coumaric Acids
/ analysis
Drug Stability
Drugs, Chinese Herbal
/ chemistry
Flavanones
/ analysis
Glucosides
/ analysis
Hesperidin
/ analogs & derivatives
Hydroxybenzoates
/ analysis
Materia Medica
/ pharmacology
Mice
Monoterpenes
/ analysis
Quality Control
RAW 264.7 Cells
Q-markers
Quality control
Xuefu Zhuyu capsule
“Spider-web” mode
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
09
03
2020
revised:
05
06
2020
accepted:
28
06
2020
pubmed:
15
7
2020
medline:
9
1
2021
entrez:
15
7
2020
Statut:
ppublish
Résumé
The selection of quality control indicators in a complex system is a key scientific issue for the study of Chinese materia medica (CMM), which is directly related to its safety and efficacy. In order to scientifically understand and control the quality of CMM, quality marker (Q-marker) has been recently raised as a new concept, which provided a novel research idea for the quality control and evaluation of CMM. By a new and integrated "spider-web" mode, Q-markers of Xuefu Zhuyu capsule (XZC) were comprehensively uncovered, conducing to great improvement of quality control of XZC. Mainly established by three dimensions derived from six variables including content, stability and activity, "spider-web" mode was constructed to evaluate Q-marker property of candidate compounds by taking regression area of the tested compounds into account. The candidate compounds with larger regression area were preferentially adopted as Q-markers, which should possess the satisfactorily integrated properties of content, stability and activity. Six compounds, naringin, isoliquiritin, paeoniflorin, protocatechuic acid, neohesperidin and ferulic acid, were identified and preferred as Q-markers of XZC. Based on "spider-web" mode, Q-markers from Xuefu Zhuyu capsule were successfully screened, which would substantially perform quality control of XZC and prove the feasibility of "spider-web" mode in solving the selection of quality control indicators from compound formulae.
Sections du résumé
BACKGROUND
BACKGROUND
The selection of quality control indicators in a complex system is a key scientific issue for the study of Chinese materia medica (CMM), which is directly related to its safety and efficacy. In order to scientifically understand and control the quality of CMM, quality marker (Q-marker) has been recently raised as a new concept, which provided a novel research idea for the quality control and evaluation of CMM.
PURPOSE
OBJECTIVE
By a new and integrated "spider-web" mode, Q-markers of Xuefu Zhuyu capsule (XZC) were comprehensively uncovered, conducing to great improvement of quality control of XZC.
METHODS
METHODS
Mainly established by three dimensions derived from six variables including content, stability and activity, "spider-web" mode was constructed to evaluate Q-marker property of candidate compounds by taking regression area of the tested compounds into account.
RESULTS
RESULTS
The candidate compounds with larger regression area were preferentially adopted as Q-markers, which should possess the satisfactorily integrated properties of content, stability and activity. Six compounds, naringin, isoliquiritin, paeoniflorin, protocatechuic acid, neohesperidin and ferulic acid, were identified and preferred as Q-markers of XZC.
CONCLUSION
CONCLUSIONS
Based on "spider-web" mode, Q-markers from Xuefu Zhuyu capsule were successfully screened, which would substantially perform quality control of XZC and prove the feasibility of "spider-web" mode in solving the selection of quality control indicators from compound formulae.
Identifiants
pubmed: 32663710
pii: S0944-7113(20)30104-5
doi: 10.1016/j.phymed.2020.153273
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Biomarkers, Pharmacological
0
Capsules
0
Coumaric Acids
0
Drugs, Chinese Herbal
0
Flavanones
0
Glucosides
0
Hydroxybenzoates
0
Materia Medica
0
Monoterpenes
0
Xue-Fu-Zhu-Yu decoction
0
peoniflorin
21AIQ4EV64
neoisoliquiritin
2Y348H1V4W
protocatechuic acid
36R5QJ8L4B
Chalcone
5S5A2Q39HX
ferulic acid
AVM951ZWST
Hesperidin
E750O06Y6O
naringin
N7TD9J649B
neohesperidin
OA5C88H3L0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
153273Informations de copyright
Copyright © 2020 Elsevier GmbH. All rights reserved.
Déclaration de conflit d'intérêts
Conflict interest The authors declare no conflict of interest.