S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders.
Affective disorder
BDNF
High-risk-study
Monozygotic twins
S100B
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
27
04
2019
revised:
15
04
2020
accepted:
10
05
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
16
2
2021
Statut:
ppublish
Résumé
The calcium binding protein S100B and brain derived neurotrophic factor (BDNF) are both biomarkers implicated in neuronal processes in the central nervous system and seem to be associated with affective disorders. Here we investigated both markers in a sample of monozygotic (MZ) twins with, at risk of and without affective disorders, aiming to evaluate whether these markers have a role as causal factors- or trait markers for affective disorders. We measured serum S100B and plasma BDNF levels in 204 monozygotic twins (MZ) with unipolar or bipolar disorder in remission or partial remission (affected), their unaffected co-twins (high-risk) and twins with no personal or family history of affective disorder (low-risk). No significant group differences in S100B and BDNF levels were found between the three groups. Exploratory analysis revealed that higher S100B levels were correlated with lower cognitive performance. The cross-sectional design cannot elucidate the two neuronal biomarkers role as causal factors. We would have preferred a higher sample size in the high- and low-risk groups. The present result did not support a role for S100B and BDNF as neither causal factors nor trait markers for affective disorders. Elevated S100B levels may associate with impaired cognition, but further studies are warranted.
Sections du résumé
BACKGROUND
The calcium binding protein S100B and brain derived neurotrophic factor (BDNF) are both biomarkers implicated in neuronal processes in the central nervous system and seem to be associated with affective disorders. Here we investigated both markers in a sample of monozygotic (MZ) twins with, at risk of and without affective disorders, aiming to evaluate whether these markers have a role as causal factors- or trait markers for affective disorders.
METHOD
We measured serum S100B and plasma BDNF levels in 204 monozygotic twins (MZ) with unipolar or bipolar disorder in remission or partial remission (affected), their unaffected co-twins (high-risk) and twins with no personal or family history of affective disorder (low-risk).
RESULTS
No significant group differences in S100B and BDNF levels were found between the three groups. Exploratory analysis revealed that higher S100B levels were correlated with lower cognitive performance.
LIMITATIONS
The cross-sectional design cannot elucidate the two neuronal biomarkers role as causal factors. We would have preferred a higher sample size in the high- and low-risk groups.
CONCLUSION
The present result did not support a role for S100B and BDNF as neither causal factors nor trait markers for affective disorders. Elevated S100B levels may associate with impaired cognition, but further studies are warranted.
Identifiants
pubmed: 32664008
pii: S0165-0327(19)31101-2
doi: 10.1016/j.jad.2020.05.015
pii:
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
S100 Calcium Binding Protein beta Subunit
0
S100B protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
726-732Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing interest MV has received consultancy fees from Lundbeck, Sunovion and Janssen in the past three years. LVK has within the preceding three years been a consultant for Sunovion and Lundbeck. KWM has received consultancy fees from Lundbeck, Allergan and Janssen in the past three years. The remaining authors declare no conflicts of interest.