Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review.
aquatic organism
cell
magnetic nanoparticle
rodent
toxicity
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
10 Jul 2020
10 Jul 2020
Historique:
received:
02
06
2020
revised:
03
07
2020
accepted:
07
07
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
26
2
2021
Statut:
epublish
Résumé
The noteworthy intensification in the development of nanotechnology has led to the development of various types of nanoparticles. The diverse applications of these nanoparticles make them desirable candidate for areas such as drug delivery, coasmetics, medicine, electronics, and contrast agents for magnetic resonance imaging (MRI) and so on. Iron oxide magnetic nanoparticles are a branch of nanoparticles which is specifically being considered as a contrast agent for MRI as well as targeted drug delivery vehicles, angiogenic therapy and chemotherapy as small size gives them advantage to travel intravascular or intracavity actively for drug delivery. Besides the mentioned advantages, the toxicity of the iron oxide magnetic nanoparticles is still less explored. For in vivo applications magnetic nanoparticles should be nontoxic and compatible with the body fluids. These particles tend to degrade in the body hence there is a need to understand the toxicity of the particles as whole and degraded products interacting within the body. Some nanoparticles have demonstrated toxic effects such inflammation, ulceration, and decreases in growth rate, decline in viability and triggering of neurobehavioral alterations in plants and cell lines as well as in animal models. The cause of nanoparticles' toxicity is attributed to their specific characteristics of great surface to volume ratio, chemical composition, size, and dosage, retention in body, immunogenicity, organ specific toxicity, breakdown and elimination from the body. In the current review paper, we aim to sum up the current knowledge on the toxic effects of different magnetic nanoparticles on cell lines, marine organisms and rodents. We believe that the comprehensive data can provide significant study parameters and recent developments in the field. Thereafter, collecting profound knowledge on the background of the subject matter, will contribute to drive research in this field in a new sustainable direction.
Identifiants
pubmed: 32664325
pii: molecules25143159
doi: 10.3390/molecules25143159
pmc: PMC7397295
pii:
doi:
Substances chimiques
Ferric Compounds
0
Magnetite Nanoparticles
0
ferric oxide
1K09F3G675
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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