Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors.
ATM
ATR
DNA damage
HPV
Tip60
sirtuins
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
10 07 2020
10 07 2020
Historique:
received:
24
06
2020
revised:
04
07
2020
accepted:
07
07
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
23
2
2021
Statut:
epublish
Résumé
Human papillomaviruses are the causative agents of cervical and other anogenital cancers along with approximately 60% of oropharyngeal cancers. These small double-stranded DNA viruses infect stratified epithelia and link their productive life cycles to differentiation. HPV proteins target cellular factors, such as those involved in DNA damage repair, as well as epigenetic control of host and viral transcription to regulate the productive life cycle. HPVs constitutively activate the ATM and ATR DNA repair pathways and preferentially recruit these proteins to viral genomes to facilitate productive viral replication. In addition, the sirtuin deacetylases along with histone acetyltransferases, including Tip60, are targeted in HPV infections to regulate viral transcription and replication. These pathways provide potential targets for drug therapy to treat HPV-induced disease.
Identifiants
pubmed: 32664381
pii: v12070744
doi: 10.3390/v12070744
pmc: PMC7412114
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA059655
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI133984
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA142861
Pays : United States
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