Venous Thromboembolism in Children: From Diagnosis to Management.
diagnosis
paediatrics
risk factors
thrombosis
treatment
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
11 07 2020
11 07 2020
Historique:
received:
25
05
2020
revised:
24
06
2020
accepted:
07
07
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
31
10
2020
Statut:
epublish
Résumé
Venous thromboembolism (VTE) in children is a rare occurrence, although in recent decades we have seen an increase due to several factors, such as the rise in survival of subjects with chronic conditions, the use of catheters, and the increased sensitivity of diagnostic tools. Besides inherited thrombophilia, acquired conditions such as cardiovascular diseases, infections, chronic disorders, obesity and malignancy are also common risk factors for paediatric VTE. The treatment of paediatric VTE consists of the use of heparins and/or vitamin K antagonists to prevent dissemination, embolization, and secondary VTE. Randomized clinical trials of direct oral anticoagulants in paediatric VTE are ongoing, with the aim to improve the compliance and the care of patients. We reviewed the physiological and pathological mechanisms underlying paediatric thrombosis and updated the current diagnosis and treatment options.
Identifiants
pubmed: 32664502
pii: ijerph17144993
doi: 10.3390/ijerph17144993
pmc: PMC7400059
pii:
doi:
Substances chimiques
Anticoagulants
0
Vitamin K
12001-79-5
Heparin
9005-49-6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Thromb Haemost. 2003 May;1(5):915-21
pubmed: 12871356
Turk Pediatri Ars. 2018 Mar 1;53(1):1-9
pubmed: 30083068
J Clin Endocrinol Metab. 2013 Apr;98(4):E683-93
pubmed: 23457411
Haematologica. 1997 Jul-Aug;82(4):423-8
pubmed: 9299855
Thromb Res. 2013 Jan;131 Suppl 1:S39-41
pubmed: 23452739
Thromb J. 2018 Dec 4;16:32
pubmed: 30534008
Pediatr Cardiol. 2009 Oct;30(7):1012-5
pubmed: 19582499
J Pediatr. 2009 Jul;155(1):100-4
pubmed: 19324372
Pediatr Hematol Oncol. 2015 Feb;32(1):1-10
pubmed: 25325764
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):1-9
pubmed: 27913455
Semin Thromb Hemost. 2016 Oct;42(7):741-751
pubmed: 27706533
Front Pediatr. 2017 Feb 06;5:12
pubmed: 28220143
Acta Med Port. 2018 Sep 28;31(9):489-495
pubmed: 30332373
Blood. 2020 Jan 30;135(5):335-343
pubmed: 31917400
J Thromb Haemost. 2020 Jul;18(7):1672-1685
pubmed: 32246743
Front Pediatr. 2017 Mar 14;5:50
pubmed: 28352625
Adv Exp Med Biol. 2017;906:149-165
pubmed: 27628011
J Pediatr Hematol Oncol. 2013 Jul;35(5):348-55
pubmed: 23619106
Pediatr Res. 2000 Jun;47(6):763-6
pubmed: 10832734
Front Pediatr. 2017 Jul 24;5:158
pubmed: 28791278
Pediatr Hematol Oncol. 2000 Dec;17(8):667-72
pubmed: 11127398
Thromb Res. 2009 Apr;123(6):805-9
pubmed: 19167028
Thromb Res. 2006;118(1):123-35
pubmed: 16709481
Horm Res Paediatr. 2012;78(3):158-64
pubmed: 23052543
Blood. 2006 Jan 1;107(1):21-9
pubmed: 16099882
Lancet Haematol. 2020 Jan;7(1):e18-e27
pubmed: 31699660
Eur J Epidemiol. 2013 Aug;28(8):621-47
pubmed: 23900608
Biologics. 2010 Mar 24;4:51-60
pubmed: 20376174
Expert Rev Hematol. 2016 Oct;9(10):965-75
pubmed: 27677803
Br J Haematol. 2009 Aug;146(4):369-83
pubmed: 19552721
Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):399-404
pubmed: 30504338
J Pediatr. 2016 Apr;171:60-6.e1
pubmed: 26787378
Blood. 2007 Apr 15;109(8):3161-72
pubmed: 17110453
Blood Coagul Fibrinolysis. 2011 Jul;22(5):351-61
pubmed: 21681083
Semin Thromb Hemost. 1997;23(3):321-32
pubmed: 9255912
J Thromb Haemost. 2003 May;1(5):958-62
pubmed: 12871361
Semin Thromb Hemost. 2011 Oct;37(7):794-801
pubmed: 22187402
Hematol Oncol Clin North Am. 2010 Feb;24(1):151-66
pubmed: 20113900
Expert Rev Hematol. 2018 Jan;11(1):37-44
pubmed: 29183221
Pediatr Clin North Am. 2013 Dec;60(6):1443-62
pubmed: 24237981
Curr Opin Pediatr. 2014 Jun;26(3):286-91
pubmed: 24732566
Acta Paediatr. 1997 Oct;86(10):1100-4
pubmed: 9350893
Expert Rev Hematol. 2016 Dec;9(12):1139-1149
pubmed: 27797270
Blood. 1999 Nov 1;94(9):3007-14
pubmed: 10556183
Int J Cardiol. 2014 Jun 15;174(2):343-7
pubmed: 24794964
J Atheroscler Thromb. 2016 Aug 1;23(8):950-9
pubmed: 26903398
Recent Pat Cardiovasc Drug Discov. 2007 Jan;2(1):53-62
pubmed: 18221103
J Clin Oncol. 2005 Jun 20;23(18):4006-8
pubmed: 15767646
Blood. 2004 Feb 15;103(4):1192-201
pubmed: 12907438
Blood Adv. 2018 Nov 27;2(22):3292-3316
pubmed: 30482766
Lancet Haematol. 2019 Oct;6(10):e500-e509
pubmed: 31420317
Eur J Pediatr. 2011 Jul;170(7):845-50
pubmed: 21210148
Circulation. 2008 Sep 23;118(13):1373-82
pubmed: 18779442
Thromb Haemost. 2013 Oct;110(4):697-705
pubmed: 23846575
Haematologica. 2001 Oct;86(10):1112-3
pubmed: 11602424
Blood. 2015 Dec 10;126(24):2541-7
pubmed: 26500341
Chest. 2012 Feb;141(2 Suppl):e419S-e496S
pubmed: 22315268
Eur J Cardiovasc Prev Rehabil. 2011 Dec;18(6):831-5
pubmed: 21450599
Blood Coagul Fibrinolysis. 2014 Mar;25(2):97-106
pubmed: 24477225
J Pediatr. 1998 Dec;133(6):770-6
pubmed: 9842042
Chest. 2012 Feb;141(2 Suppl):e737S-e801S
pubmed: 22315277
J Pediatr Hematol Oncol. 2005 Mar;27(3):153-7
pubmed: 15750448
Pediatr Blood Cancer. 2018 Jul;65(7):e27041
pubmed: 29528184
J Thromb Haemost. 2018 Feb;16(2):196-208
pubmed: 29316202
Pediatr Crit Care Med. 2017 Mar;18(3_suppl Suppl 1):S32-S45
pubmed: 28248832
Thromb J. 2018 Dec 21;16:34
pubmed: 30598642
Thromb Haemost. 2016 Jan;115(1):25-30
pubmed: 26271270
Haemostasis. 1991;21(5):300-4
pubmed: 1806458
Int J Med Sci. 2013;10(3):338-43
pubmed: 23423872
Front Pediatr. 2017 Jun 19;5:146
pubmed: 28674685
Clin J Am Soc Nephrol. 2012 Mar;7(3):513-20
pubmed: 22344511
Br J Haematol. 2018 Mar;180(5):654-665
pubmed: 29265336
J Vasc Surg. 2012 Jun;55(6):1785-93
pubmed: 21944920