Immune Transcriptome of Cells Infected with Enterovirus Strains Obtained from Cases of Type 1 Diabetes.
IL18
IL32
MCP1
autoimmunity
cytokine
diabetes
interferon
pathogenesis
persistent infection
virus
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
12 Jul 2020
12 Jul 2020
Historique:
received:
29
05
2020
revised:
06
07
2020
accepted:
10
07
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
16
7
2020
Statut:
epublish
Résumé
Enterovirus (EV) infection of insulin-producing pancreatic beta cells is associated with type 1 diabetes (T1D), but little is known about the mechanisms that lead the virus to cause a persistent infection and, possibly, to induce beta cell autoimmunity. A cell line susceptible to most enterovirus types was infected with EV isolates from cases of T1D and, for comparison, with a replication-competent strain of coxsackievirus B3. The transcription of immune-related genes and secretion of cytokines was evaluated in infected vs. uninfected cells. Acutely infected cells showed the preserved transcription of type I interferon (IFN) pathways and the enhanced transcription/secretion of
Identifiants
pubmed: 32664675
pii: microorganisms8071031
doi: 10.3390/microorganisms8071031
pmc: PMC7409211
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Juvenile Diabetes Research Foundation & nPOD-V
ID : 25-2012-770
Organisme : Italian Ministry of Health
ID : PE-2013-02357094
Organisme : Italian Ministry of University and Research (MIUR)
ID : 2015HPMLFY
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