Cognitive Impairment, Chronic Kidney Disease, and 1-Year Mortality in Older Patients Discharged from Acute Care Hospital.
Chronic kidney disease
cognitive impairment
constructional praxis
mortality
older
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
12 Jul 2020
12 Jul 2020
Historique:
received:
27
05
2020
revised:
09
07
2020
accepted:
10
07
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
16
7
2020
Statut:
epublish
Résumé
The prognostic interaction between chronic kidney disease (CKD) and cognitive impairment is still to be elucidated. We investigated the potential interaction of overall cognitive impairment or defective constructional praxis and CKD in predicting 1-year mortality among 646 older patients discharged from hospital. The estimated glomerular filtration rate (eGFR) was calculated using the Berlin Initiative Study (BIS) equation. Cognitive impairment was assessed by the Mini Mental State Exam (MMSE) and defective constructional praxis was ascertained by the inherent MMSE item. The study outcome was 1-year mortality. Statistical analysis was carried out using Cox regression. After adjusting for potential confounders, the co-occurrence of eGFR <30 and overall cognitive impairment (Hazard Ratio (HR) = 3.12, 95% Confidence Interval (CI) = 1.26-7.77) and defective constructional praxis (HR = 2.50, 95% CI = 1.08-5.77) were associated with the outcome. No significant prognostic interaction of eGFR < 30 with either overall cognitive impairment (HR = 1.99, 95% CI = 0.38-10.3) or constructional apraxia (HR = 1.68, 95% CI = 0.33-8.50) was detectable, while only cognitive deficits were found significantly associated with the outcome in the interaction models (HR = 3.12, 95% CI = 1.45-6.71 for overall cognitive impairment and HR = 2.16, 95% CI = 1.05-4.45 for constructional apraxia). Overall cognitive impairment and defective constructional praxis may be associated with increased risk of 1-year mortality among older hospitalized patients with severe CKD. However, no significant prognostic interaction between CKD and cognitive impairment could be observed.
Identifiants
pubmed: 32664677
pii: jcm9072202
doi: 10.3390/jcm9072202
pmc: PMC7408778
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero della Salute
ID : GR-2007 685638
Références
Kidney Blood Press Res. 2018;43(6):1908-1918
pubmed: 30566955
JAMA. 1963 Sep 21;185:914-9
pubmed: 14044222
J Am Soc Nephrol. 2013 Feb;24(3):353-63
pubmed: 23291474
Brain Lang. 1979 Jul;8(1):34-50
pubmed: 476474
JAMA. 1998 Feb 25;279(8):585-92
pubmed: 9486752
Lancet. 2020 Feb 29;395(10225):709-733
pubmed: 32061315
J Nutr Health Aging. 2013;17(5):435-9
pubmed: 23636544
Cell Res. 2009 Jun;19(6):672-82
pubmed: 19436263
J Gerontol A Biol Sci Med Sci. 2005 Jul;60(7):928-32
pubmed: 16079220
BMC Neurosci. 2018 Oct 17;19(1):62
pubmed: 30333009
Int J Cardiol. 2015 Jan 15;178:12-23
pubmed: 25464210
Kidney Int Rep. 2016 Sep 20;2(1):94-107
pubmed: 29318209
Sci Rep. 2018 Aug 16;8(1):12250
pubmed: 30115946
Alzheimers Dement (Amst). 2015 Jun 1;1(2):152-159
pubmed: 26005710
Am J Kidney Dis. 2005 Jan;45(1):66-76
pubmed: 15696445
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Am Geriatr Soc. 2019 Mar;67(3):477-483
pubmed: 30468258
Kidney Int. 2014 Mar;85(3):505-7
pubmed: 24583984
BMC Psychiatry. 2020 May 6;20(1):203
pubmed: 32375731
J Clin Psychol. 1994 Mar;50(2):256-60
pubmed: 8014251
Syst Rev. 2020 Mar 17;9(1):58
pubmed: 32183894
Circ Heart Fail. 2016 Dec;9(12):
pubmed: 27895069
Am J Geriatr Psychiatry. 2013 Jul;21(7):636-45
pubmed: 23567408
Curr Drug Saf. 2013 Apr;8(2):98-103
pubmed: 23713540
Nephrol Dial Transplant. 2011 Jan;26(1):360-4
pubmed: 20921298
J Clin Med. 2018 Oct 17;7(10):
pubmed: 30336612
Psychiatry Clin Neurosci. 2008 Oct;62(5):554-61
pubmed: 18950375
N Engl J Med. 2004 Sep 23;351(13):1296-305
pubmed: 15385656
Curr Diab Rep. 2019 Feb 15;19(3):11
pubmed: 30771017
Am J Kidney Dis. 2014 May;63(5):865-7
pubmed: 24560028
Clin J Am Soc Nephrol. 2009 Jun;4(6):1121-7
pubmed: 19423569
Am J Kidney Dis. 2008 Aug;52(2):227-34
pubmed: 18585836
Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):1938-1966
pubmed: 31412740
Aging Clin Exp Res. 2020 May;32(5):841-850
pubmed: 31732959
BMC Nephrol. 2018 Oct 22;19(1):285
pubmed: 30348110
Clin J Am Soc Nephrol. 2011 Jun;6(6):1400-9
pubmed: 21566108
Brain Cogn. 2009 Jun;70(1):163-70
pubmed: 19261365
Am J Nephrol. 2012;35(1):49-57
pubmed: 22189005
Dement Geriatr Cogn Disord. 2002;13(3):156-63
pubmed: 11893837
Lancet. 2017 Mar 25;389(10075):1238-1252
pubmed: 27887750
J Am Soc Nephrol. 2005 Jul;16(7):2127-33
pubmed: 15888561
Age Ageing. 2004 Jul;33(4):355-61
pubmed: 15136287
Curr Opin Nephrol Hypertens. 2016 Nov;25(6):465-472
pubmed: 27490909
Am J Kidney Dis. 2010 Mar;55(3 Suppl 2):S23-33
pubmed: 20172445
Psychol Med. 1999 Mar;29(2):485-9
pubmed: 10218940
J Alzheimers Dis. 2018;61(1):145-155
pubmed: 29154273
Nat Rev Nephrol. 2020 Aug;16(8):452-469
pubmed: 32235904
Curr Cardiol Rev. 2019;15(4):291-303
pubmed: 31456512
Chest. 2006 Dec;130(6):1687-94
pubmed: 17166983
J Bras Nefrol. 2014 Apr-Jun;36(2):241-5
pubmed: 25055365
Am J Nephrol. 2015;41(4-5):305-12
pubmed: 26201453
J Am Geriatr Soc. 2009 Jan;57(1):94-100
pubmed: 19016932
J Bras Nefrol. 2011 Mar;33(1):27-30
pubmed: 21541459
Neurology. 2006 Jul 25;67(2):216-23
pubmed: 16864811
Int J Geriatr Psychiatry. 2001 Aug;16(8):751-61
pubmed: 11536341
Am Heart J. 2007 Sep;154(3):424-31
pubmed: 17719284
J Am Geriatr Soc. 2009 Jun;57(6):985-91
pubmed: 19507292
J Aging Health. 2009 Jun;21(4):567-80
pubmed: 19339680
J Cardiovasc Med (Hagerstown). 2014 Jun;15(6):481-90
pubmed: 24983268
Am J Kidney Dis. 2016 Jul;68(1):77-83
pubmed: 26972681
Front Cell Infect Microbiol. 2019 Jun 12;9:206
pubmed: 31245306
Diabetes Care. 2012 Apr;35(4):787-93
pubmed: 22374637
Chest. 2006 Dec;130(6):1636-8
pubmed: 17166974
Clin Interv Aging. 2017 Jul 04;12:1049-1054
pubmed: 28740370
Ann Intern Med. 2012 Oct 2;157(7):471-81
pubmed: 23027318