Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing.
Algorithms
Antiviral Agents
/ therapeutic use
Betacoronavirus
/ drug effects
COVID-19
Computer Simulation
Coronavirus Infections
/ drug therapy
Drug Repositioning
/ methods
Host Microbial Interactions
/ physiology
Humans
Internet
Pandemics
Pneumonia, Viral
/ drug therapy
Protein Interaction Maps
SARS-CoV-2
Virus Attachment
/ drug effects
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
received:
23
04
2020
accepted:
12
06
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very time-consuming to integrate, and exploit. We develop CoVex, an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. We investigate recent hypotheses on a systems biology level to explore mechanistic virus life cycle drivers, and to extract drug repurposing candidates. CoVex renders COVID-19 drug research systems-medicine-ready by giving the scientific community direct access to network medicine algorithms. It is available at https://exbio.wzw.tum.de/covex/.
Identifiants
pubmed: 32665542
doi: 10.1038/s41467-020-17189-2
pii: 10.1038/s41467-020-17189-2
pmc: PMC7360763
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3518Subventions
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Societal Challenges | H2020 Health (H2020 Societal Challenges - Health, Demographic Change and Well-being)
ID : 777111
Pays : International
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