Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis.
Adolescent
Adult
Aged
Arthritis, Rheumatoid
/ genetics
Biological Variation, Population
/ genetics
Child
Child, Preschool
Diabetes Mellitus, Type 1
/ genetics
Epigenesis, Genetic
/ genetics
Female
Genetic Predisposition to Disease
Genetics, Population
Genomic Imprinting
/ genetics
Genotype
Humans
Infant
Male
Maternal Inheritance
/ genetics
Middle Aged
Pedigree
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
received:
11
03
2020
accepted:
18
06
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Imprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may also play a role. By using a mixed model that is able to simultaneously consider all kinds of POEs, the importance of POEs for the development of T1D and RA was investigated in a variance components analysis. The analysis was based on Swedish population-scale pedigree data. With P = 0.18 (T1D) and P = 0.26 (RA) imprinting variances were not significant. Explaining up to 19.00% (± 2.00%) and 15.00% (± 6.00%) of the phenotypic variance, the maternal environmental variance was significant for T1D (P = 1.60 × 10
Identifiants
pubmed: 32665606
doi: 10.1038/s41598-020-68212-x
pii: 10.1038/s41598-020-68212-x
pmc: PMC7360775
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11562Références
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