Zika virus vertical transmission in children with confirmed antenatal exposure.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
received:
27
01
2020
accepted:
22
06
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
1
9
2020
Statut:
epublish
Résumé
We report Zika virus (ZIKV) vertical transmission in 130 infants born to PCR+ mothers at the time of the Rio de Janeiro epidemic of 2015-2016. Serum and urine collected from birth through the first year of life were tested by quantitative reverse transcriptase polymerase chain reaction (PCR) and/or IgM Zika MAC-ELISA. Four hundred and seven specimens are evaluated; 161 sera tested by PCR and IgM assays, 85 urines by PCR. Sixty-five percent of children (N = 84) are positive in at least one assay. Of 94 children tested within 3 months of age, 70% are positive. Positivity declines to 33% after 3 months. Five children are PCR+ beyond 200 days of life. Concordance between IgM and PCR results is 52%, sensitivity 65%, specificity 40% (positive PCR results as gold standard). IgM and serum PCR are 61% concordant; serum and urine PCR 55%. Most children (65%) are clinically normal. Equal numbers of children with abnormal findings (29 of 45, 64%) and normal findings (55 of 85, 65%) have positive results, p = 0.98. Earlier maternal trimester of infection is associated with positive results (p = 0.04) but not clinical disease (p = 0.98). ZIKV vertical transmission is frequent but laboratory confirmed infection is not necessarily associated with infant abnormalities.
Identifiants
pubmed: 32665616
doi: 10.1038/s41467-020-17331-0
pii: 10.1038/s41467-020-17331-0
pmc: PMC7360785
doi:
Substances chimiques
Immunoglobulin M
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3510Subventions
Organisme : NIAID NIH HHS
ID : K08 AI141728
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI069120
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140718
Pays : United States
Organisme : Wellcome Trust
ID : 205377/Z/16/Z
Pays : United Kingdom
Références
Calvet, G. A. et al. First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil. J. Clin. Virol. 74, 1–3 (2016).
doi: 10.1016/j.jcv.2015.11.014
Brasil, P. et al. Zika virus infection in pregnant women in Rio de Janeiro. N. Engl. J. Med. 375, 2321–2334 (2016).
Lopes Moreira, M. E. et al. Neurodevelopment in infants exposed to Zika virus in utero. N. Engl. J. Med. 379, 2377–2379 (2018).
doi: 10.1056/NEJMc1800098
Nielsen-Saines, K. et al. Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children. Nat. Med. 25, 1213–1217 (2019).
doi: 10.1038/s41591-019-0496-1
Einspieler, C. et al. Association of infants exposed to prenatal Zika virus infection with their clinical, neurologic, and developmental status evaluated via the general movement assessment tool. JAMA Netw. Open 2, e187235 (2019).
doi: 10.1001/jamanetworkopen.2018.7235
Adachi, K. & Nielsen-Saines, K. Zika clinical updates: implications for pediatrics. Curr. Opin. Pediatr. 30, 105–116 (2018).
doi: 10.1097/MOP.0000000000000582
Pereira, J. P. et al. The role of amniocentesis in the diagnosis of congenital Zika syndrome. Clin. Infect. Dis. 69, 713–716 (2019).
doi: 10.1093/cid/ciz013
Paz-Bailey, G. et al. Persistence of Zika virus in body fluids. N. Engl. J. Med. 379, 1234–1243 (2018).
doi: 10.1056/NEJMoa1613108
Sanchez-Montalva, A., Salvador, F. & Molina, I. Persistence of Zika virus in body fluids. N. Engl. J. Med. 380, 198 (2019).
doi: 10.1056/NEJMc1814416
Braga, J. U. et al. Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics. PLoS ONE 12, e0179725 (2017).
doi: 10.1371/journal.pone.0179725
Lanciotti, R. S. et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg. Infect. Dis. 14, 1232–1239 (2008).
doi: 10.3201/eid1408.080287
Pastuszak, A. L. et al. Outcome after maternal varicella infection in the first 20 weeks of pregnancy. N. Engl. J. Med. 330, 901–905 (1994).
doi: 10.1056/NEJM199403313301305
Harrison, G. J. in Feigin and Cherry’s Textbook of Pediatric Infectious Diseases (eds Harrison, J. D., Cherry, G. J., Kaplan, S. L. et al.) 1429 (Elsevier Saunders, 2019).
Cherry, J. D. B. A. in Feigin and Cherry’s Textbook of Pediatric Infectious Diseases (eds Cherry, J., Harrison, G. J. & Kaplan, S. L.) 1601 (Elsevier Saunders, 2019).
Pomar, L. et al. Maternal-fetal transmission and adverse perinatal outcomes in pregnant women infected with Zika virus: prospective cohort study in French Guiana. BMJ 363, k4431 (2018).
doi: 10.1136/bmj.k4431
Conners, E. E. et al. Zika virus infection among pregnant women and their neonates in New York City, January 2016–June 2017. Obstet. Gynecol. 132, 487–495 (2018).
doi: 10.1097/AOG.0000000000002737
Adebanjo, T. et al. Update: Interim guidance for the diagnosis, evaluation, and management of infants with possible congenital Zika virus infection - United States, October 2017. MMWR Morb. Mortal. Wkly Rep. 66, 1089–1099 (2017).
doi: 10.15585/mmwr.mm6641a1
Sharp, T. M. et al. Dengue and Zika virus diagnostic testing for patients with a clinically compatible illness and risk for infection with both viruses. MMWR Recomm. Rep. 68, 1–10 (2019).
doi: 10.15585/mmwr.rr6801a1
Fuller, T. L. et al. Behavioral, climatic, and environmental risk factors for Zika and Chikungunya virus infections in Rio de Janeiro, Brazil, 2015-16. PLoS ONE 12, e0188002 (2017).
doi: 10.1371/journal.pone.0188002
Theel, E. S. & Hata, D. J. Diagnostic testing for Zika virus: a postoutbreak update. J. Clin. Microbiol. 56, https://doi.org/10.1128/JCM.01972-17 (2018).
Tan, S. K., Sahoo, M. K., Milligan, S. B., Taylor, N. & Pinsky, B. A. Stability of Zika virus in urine: Specimen processing considerations and implications for the detection of RNA targets in urine. J. Virol. Methods 248, 66–70 (2017).
doi: 10.1016/j.jviromet.2017.04.018
Halai, U. A. et al. Maternal Zika virus disease severity, virus load, prior dengue antibodies, and their relationship to birth outcomes. Clin. Infect. Dis. 65, 877–883 (2017).
doi: 10.1093/cid/cix472
Vasconcelos, Z., Azevedo, R. C. & Zin, A. ZIKV Diagnostics: Current Scenario and Future Directions (2018).
Granger, D. et al. Serologic testing for Zika virus: comparison of three Zika virus IgM-screening enzyme-linked immunosorbent assays and initial laboratory experiences. J. Clin. Microbiol. 55, 2127–36 (2017).
doi: 10.1128/JCM.00580-17
von der Hagen, M. et al. Diagnostic approach to microcephaly in childhood: a two-center study and review of the literature. Dev. Med. Child Neurol. 56, 732–741 (2014).
doi: 10.1111/dmcn.12425
Villar, J. et al. International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet 384, 857–868 (2014).
doi: 10.1016/S0140-6736(14)60932-6
Tsui, I. et al. Eye findings in infants with suspected or confirmed antenatal Zika virus exposure. Pediatrics 142, https://doi.org/10.1542/peds.2018-1104 (2018).
Zin, A. A. et al. Screening criteria for ophthalmic manifestations of congenital Zika virus infection. JAMA Pediatr. 171, 847–854 (2017).
doi: 10.1001/jamapediatrics.2017.1474
de Paula Freitas, B. et al. Anterior-segment ocular findings and microphthalmia in congenital Zika syndrome. Ophthalmology 124, 1876–1878 (2017).
doi: 10.1016/j.ophtha.2017.06.009
Zin, A. A. et al. Visual function in infants with antenatal Zika virus exposure. J. AAPOS 22, 452–456 (2018).
doi: 10.1016/j.jaapos.2018.07.352
Pool, K. L. et al. Association between neonatal neuroimaging and clinical outcomes in Zika-exposed infants from Rio de Janeiro, Brazil. JAMA Netw. Open 2, e198124 (2019).
doi: 10.1001/jamanetworkopen.2019.8124
Johnson, S., Moore, T. & Marlow, N. Using the Bayley-III to assess neurodevelopmental delay: which cut-off should be used? Pediatr. Res. 75, 670–674 (2014).
doi: 10.1038/pr.2014.10