Bone turnover markers in serum but not in saliva correlate with bone mineral density.
Aged
Biomarkers
/ metabolism
Bone Density
Bone Remodeling
Bone and Bones
/ physiology
Case-Control Studies
Collagen Type I
/ metabolism
Cross-Sectional Studies
Female
Femur Neck
/ metabolism
Humans
Kinetics
Lumbar Vertebrae
/ metabolism
Middle Aged
Osteocalcin
/ blood
Osteoporosis, Postmenopausal
/ blood
Outpatients
Peptides
/ metabolism
Prognosis
Saliva
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
received:
03
10
2019
accepted:
10
06
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
23
1
2021
Statut:
epublish
Résumé
Saliva was proposed as a diagnostic tool for systemic diseases. Here we determined the correlation of bone turnover markers in saliva, bone turnover markers in serum and bone mineral density in postmenopausal osteoporotic and healthy women. Forty postmenopausal osteoporotic and 40 age-matched healthy non-osteoporotic females were recruited for this case-control study. Serum and stimulated saliva levels of osteocalcin, N-terminal propeptide of type I collagen, bone-specific alkaline phosphatase and cross-linked-C-telopeptide of type I collagen were determined. Bone mineral density of the lumbar spine, proximal femur, and total hip were obtained. We show that osteocalcin and cross-linked-C-telopeptide of type I collagen (CTX) reached detectable levels in saliva while N-terminal propeptide of type I collagen and alkaline phosphatase were close or below the detection limit. Serum levels of bone turnover markers were significantly higher than saliva levels. Correlation analysis revealed a strong correlation of serum osteocalcin and, to a lesser extent, also serum CTX values with bone mineral density in lumbar spine, femoral neck, or total hip, respectively. There was, however, no significant correlation of bone mineral density with the respective bone turnover markers in saliva. There was a trend that saliva osteocalcin correlates with femoral neck (p = 0.16) or total hip (p = 0.06). There was also no association between serum and saliva bone turnover markers. This study reveals that saliva cannot replace the withdrawal of serum to evaluate bone metabolism.
Identifiants
pubmed: 32665632
doi: 10.1038/s41598-020-68442-z
pii: 10.1038/s41598-020-68442-z
pmc: PMC7360752
doi:
Substances chimiques
Biomarkers
0
Collagen Type I
0
Peptides
0
collagen type I trimeric cross-linked peptide
0
Osteocalcin
104982-03-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11550Subventions
Organisme : Austrian Science Fund FWF
ID : I 4072
Pays : Austria
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