Lessons learned from the mechanisms of posttraumatic inflammation extrapolated to the inflammatory response in COVID-19: a review.
ARDS
Covid-19
Inflammation
SARS-CoV-2
Severe trauma, critical care
Journal
Patient safety in surgery
ISSN: 1754-9493
Titre abrégé: Patient Saf Surg
Pays: England
ID NLM: 101319176
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
05
2020
accepted:
17
06
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
16
7
2020
Statut:
epublish
Résumé
Up to 20% of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) patients develop severe inflammatory complications with diffuse pulmonary inflammation, reflecting acute respiratory distress syndrome (ARDS). A similar clinical profile occurs in severe trauma cases. This review compares pathophysiological and therapeutic principles of severely injured trauma patients and severe coronavirus disease 2019 (COVID-19). The development of sequential organ failure in trauma parallels deterioration seen in severe COVID-19. Based on established pathophysiological models in the field of trauma, two complementary pathways of disease progression into severe COVID-19 have been identified. Furthermore, the transition from local contained disease into systemic and remote inflammation has been addressed. More specifically, the traumatology concept of sequential insults ('hits') resulting in immune dysregulation, is applied to COVID-19 disease progression modelling. Finally, similarities in post-insult humoral and cellular immune responses to severe trauma and severe COVID-19 are described. To minimize additional 'hits' to COVID-19 patients, we suggest postponing all elective surgery in endemic areas. Based on traumatology experience, we propose that immunoprotective protocols including lung protective ventilation, optimal thrombosis prophylaxis, secondary infection prevention and calculated antibiotic therapy are likely also beneficial in the treatment of SARS-CoV-2 infections. Finally, rising SARS-CoV-2 infection and mortality rates mandate exploration of out-of-the box treatment concepts, including experimental therapies designed for trauma care.
Identifiants
pubmed: 32665786
doi: 10.1186/s13037-020-00253-7
pii: 253
pmc: PMC7346848
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
28Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsWe (We represents all listed authors (MT, RP, HT, LB, SH, AS, HCP) wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.
Références
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
J Infect Dis. 2020 Jun 30;:
pubmed: 32601708
Shock. 1997 Jul;8(1):16-25
pubmed: 9249908
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Rev Esp Cardiol. 2011 Jul;64(7):551-3
pubmed: 21616576
Semin Immunopathol. 2017 Jul;39(5):529-539
pubmed: 28466096
Zhonghua Shao Shang Za Zhi. 2020 Mar 16;36(0):E006
pubmed: 32174095
Lancet Infect Dis. 2020 May;20(5):565-574
pubmed: 32213337
J Exp Med. 2011 Dec 19;208(13):2581-90
pubmed: 22110166
J Inflamm (Lond). 2018 May 24;15:11
pubmed: 29849508
J Pathol. 2006 Nov;210(3):288-97
pubmed: 17031779
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
J Cell Mol Med. 2015 Nov;19(11):2655-63
pubmed: 26282710
Zhonghua Bing Li Xue Za Zhi. 2020 May 8;49(5):411-417
pubmed: 32172546
Curr Opin Pharmacol. 2011 Aug;11(4):397-403
pubmed: 21741310
Unfallchirurg. 2005 Oct;108(10):793-4, 796-803
pubmed: 16175346
J Trauma Acute Care Surg. 2018 Aug 17;85(6):1081-1091
pubmed: 30124627
Nat Med. 2020 Apr;26(4):453-455
pubmed: 32284614
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Lancet. 2003 May 24;361(9371):1767-72
pubmed: 12781535
Clin Res Cardiol. 2020 May;109(5):531-538
pubmed: 32161990
Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):585-594
pubmed: 30570487
Eur Heart J. 2020 May 14;41(19):1858
pubmed: 32227120
PLoS One. 2017 Oct 30;12(10):e0187015
pubmed: 29084247
Thorax. 2002 Jun;57(6):540-6
pubmed: 12037231
Ann Intensive Care. 2012 Jul 12;2(1):27
pubmed: 22788849
Am J Respir Crit Care Med. 1995 Feb;151(2 Pt 1):293-301
pubmed: 7842182
J Exp Med. 2005 Aug 1;202(3):415-24
pubmed: 16043521
Lancet Infect Dis. 2020 Jun;20(6):656-657
pubmed: 32199493
Injury. 2009 Sep;40(9):907-11
pubmed: 19540488
J Trauma Acute Care Surg. 2020 Jun;88(6):713-714
pubmed: 32281766
Exp Anim. 2018 Jul 30;67(3):313-320
pubmed: 29398669
N Engl J Med. 2020 Apr 30;382(18):e41
pubmed: 32212516
JAMA Intern Med. 2020 Mar 13;:
pubmed: 32167524
J Med Virol. 2020 May;92(5):491-494
pubmed: 32056249
J Trauma Acute Care Surg. 2017 Sep;83(3):496-506
pubmed: 28590348
J Pathol. 2004 Jun;203(2):622-30
pubmed: 15141376
Viruses. 2020 Jan 24;12(2):
pubmed: 31991541
Lancet Infect Dis. 2020 Jun;20(6):669-677
pubmed: 32240634
Intensive Care Med. 2004 Jun;30(6):1228-31
pubmed: 15105985
Intensive Care Med. 2020 May;46(5):846-848
pubmed: 32125452
Crit Care. 2009;13(6):R174
pubmed: 19887013
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Cochrane Database Syst Rev. 2015 Aug 14;(8):CD007798
pubmed: 26272489
Circ Res. 2000 Sep 1;87(5):E1-9
pubmed: 10969042
Nature. 2005 Jul 7;436(7047):112-6
pubmed: 16001071
Neuroimmunomodulation. 2012;19(1):10-9
pubmed: 22067617
JAMA. 2020 Feb 7;:
pubmed: 32031570
J Surg Res. 2013 Mar;180(1):125-32
pubmed: 23122584
Injury. 2005 Jun;36(6):691-709
pubmed: 15910820
Nat Rev Microbiol. 2009 Jun;7(6):439-50
pubmed: 19430490
Crit Care Med. 2014 Oct;42(10):2278-89
pubmed: 25098333
mBio. 2014 Feb 25;5(2):e00884-14
pubmed: 24570370
Semin Immunopathol. 2017 Jul;39(5):505-516
pubmed: 28451786
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Lancet. 2014 Oct 18;384(9952):1455-65
pubmed: 25390327
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
Ann Surg. 1993 Dec;218(6):769-76
pubmed: 8257227
J Trauma. 2001 Sep;51(3):452-6; discussion 456-7
pubmed: 11535890
J Trauma. 2003 Jul;55(1):7-13
pubmed: 12855874
J Trauma. 1996 Apr;40(4):501-10; discussion 510-2
pubmed: 8614027
Nat Med. 2005 Aug;11(8):875-9
pubmed: 16007097
Crit Care Med. 2000 Oct;28(10):3441-8
pubmed: 11057799
BMC Emerg Med. 2015 Sep 16;15:22
pubmed: 26376825
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Clin Infect Dis. 2003 Sep 15;37(6):857-9
pubmed: 12955652
Cochrane Database Syst Rev. 2013 Feb 28;(2):CD003844
pubmed: 23450544
Lancet. 2003 May 24;361(9371):1773-8
pubmed: 12781536
Lancet Respir Med. 2020 May;8(5):475-481
pubmed: 32105632
Crit Care Med. 2012 Aug;40(8):2295-303
pubmed: 22809905
Front Immunol. 2019 Jun 14;10:1348
pubmed: 31258531