Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia.
COVID-19
computed tomography
coronavirus
corticosteroids
cytokine storm syndrome
Journal
European journal of case reports in internal medicine
ISSN: 2284-2594
Titre abrégé: Eur J Case Rep Intern Med
Pays: Italy
ID NLM: 101648453
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
06
2020
accepted:
20
06
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
16
7
2020
Statut:
epublish
Résumé
In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19). We describe a patient with rapid worsening of COVID-19 pneumonia and its dramatic improvement under corticosteroids. Corticosteroids could be useful in patients with an inflammatory profile, considering that acute respiratory distress syndrome may be the consequence of cytokine storm syndrome. One of the main pathophysiological hypotheses for severe COVID-19 pneumonia is inappropriate immunological hyperactivation.Corticosteroid therapy may be useful in these patients.
Sections du résumé
BACKGROUND
BACKGROUND
In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19).
CASE DESCRIPTION
METHODS
We describe a patient with rapid worsening of COVID-19 pneumonia and its dramatic improvement under corticosteroids.
DISCUSSION
CONCLUSIONS
Corticosteroids could be useful in patients with an inflammatory profile, considering that acute respiratory distress syndrome may be the consequence of cytokine storm syndrome.
LEARNING POINTS
CONCLUSIONS
One of the main pathophysiological hypotheses for severe COVID-19 pneumonia is inappropriate immunological hyperactivation.Corticosteroid therapy may be useful in these patients.
Identifiants
pubmed: 32665942
doi: 10.12890/2020_001822
pii: 1822-1-14859-1-10-20200702
pmc: PMC7350974
doi:
Types de publication
Journal Article
Langues
eng
Pagination
001822Informations de copyright
© EFIM 2020.
Déclaration de conflit d'intérêts
Conflicts of Interests: The Authors declare that there are no competing interests.
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