TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
Activating Transcription Factor 4
/ metabolism
Collagen
/ biosynthesis
Fibroblasts
/ drug effects
Glycine
/ metabolism
Glycolysis
/ drug effects
Humans
Lung
/ cytology
Mechanistic Target of Rapamycin Complex 1
/ metabolism
Mitochondria
/ drug effects
Oxygen Consumption
/ drug effects
Phosphatidylinositol 3-Kinases
/ metabolism
Proto-Oncogene Proteins c-akt
/ metabolism
Serine
/ metabolism
Signal Transduction
/ drug effects
Stress, Physiological
TOR Serine-Threonine Kinases
/ metabolism
Transforming Growth Factor beta
/ pharmacology
fibrosis
glycolysis
metabolism
mitochondria
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
pubmed:
16
7
2020
medline:
15
12
2020
entrez:
16
7
2020
Statut:
ppublish
Résumé
Idiopathic pulmonary fibrosis is a fatal interstitial lung disease characterized by the TGF-β (transforming growth factor-β)-dependent differentiation of lung fibroblasts into myofibroblasts, which leads to excessive deposition of collagen proteins and progressive scarring. We have previously shown that synthesis of collagen by myofibroblasts requires
Identifiants
pubmed: 32668192
doi: 10.1165/rcmb.2020-0143OC
pmc: PMC7605163
doi:
Substances chimiques
Transforming Growth Factor beta
0
Activating Transcription Factor 4
145891-90-3
Serine
452VLY9402
Collagen
9007-34-5
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Glycine
TE7660XO1C
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
601-612Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL144454
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151680
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007605
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES026718
Pays : United States
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