Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium.

Alzheimer Disease / genetics Animals Animals, Genetically Modified Brain / metabolism Calcium / metabolism Cell Nucleus / metabolism Cyclic AMP Response Element-Binding Protein / metabolism Drosophila melanogaster / genetics Gene Expression Profiling Gene Expression Regulation Induced Pluripotent Stem Cells / metabolism Membrane Potentials Neurons / metabolism Neurotoxins / toxicity tau Proteins / metabolism
Alzheimer’s disease BK channels CREB Drosophila calcium iPSC-derived neurons neurodegeneration nucleus tau tauopathy

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
14 07 2020
Historique:
received: 01 01 2020
revised: 06 05 2020
accepted: 22 06 2020
entrez: 16 7 2020
pubmed: 16 7 2020
medline: 30 4 2021
Statut: ppublish

Résumé

Synaptic activity-induced calcium (Ca

Identifiants

DOI: 10.1016/j.celrep.2020.107900 PMID: 32668249 PMC: PMC7428851
pubmed: 32668249
pii: S2211-1247(20)30881-0
doi: 10.1016/j.celrep.2020.107900
pmc: PMC7428851
mid: NIHMS1612497
pii:
doi:

Substances chimiques

Cyclic AMP Response Element-Binding Protein 0
Neurotoxins 0
tau Proteins 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

107900

Subventions

Organisme : NIDCR NIH HHS
ID : R21 DE030603
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA054174
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS082145
Pays : United States
Organisme : NIH HHS
ID : S10 OD021805
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002647
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062475
Pays : United States
Organisme : NIGMS NIH HHS
ID : K12 GM111726
Pays : United States

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Références

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Auteurs

Rebekah Mahoney (R)

Barshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA.

Elizabeth Ochoa Thomas (E)

Barshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA.

Paulino Ramirez (P)

Barshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA.

Henry E Miller (HE)

Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA; Greehey Children's Cancer Institute, University of Texas Health, San Antonio, San Antonio, TX, USA.

Adrian Beckmann (A)

Barshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA.

Gabrielle Zuniga (G)

Barshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA.

Radek Dobrowolski (R)

Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Rutgers University, Newark, NJ, USA.

Bess Frost (B)

Barshop Institute for Longevity and Aging Studies, University of Texas Health, San Antonio, San Antonio, TX, USA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Cell Systems and Anatomy, University of Texas Health, San Antonio, San Antonio, TX, USA. Electronic address: bfrost@uthscsa.edu.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Eucaryotes › Animaux › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéine de liaison à l'élément de réponse à l'AMP cyclique › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Cellules › Neurones › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Neurotoxines › Pathogenic Tau Causes a Toxic Depletion of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Pathogenic Tau Causes a Toxic Depletion of...