Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.

Alzheimer Disease / genetics Animals Brain / metabolism Case-Control Studies Disease Models, Animal Female Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Humans Male Mice Sex Characteristics Species Specificity Transcription, Genetic Transcriptome / genetics
Alzheimer's disease RNA-seq aging coexpression analysis differential expression analysis meta-analysis mouse models neuroinflammation transcriptome

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
14 07 2020
Historique:
received: 02 01 2019
revised: 01 06 2020
accepted: 24 06 2020
entrez: 16 7 2020
pubmed: 16 7 2020
medline: 30 4 2021
Statut: ppublish

Résumé

We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples. We discover 30 brain coexpression modules from seven regions as the major source of AD transcriptional perturbations. We next examine overlap with 251 brain differentially expressed gene sets from mouse models of AD and other neurodegenerative disorders. Human-mouse overlaps highlight responses to amyloid versus tau pathology and reveal age- and sex-dependent expression signatures for disease progression. Human coexpression modules enriched for neuronal and/or microglial genes broadly overlap with mouse models of AD, Huntington's disease, amyotrophic lateral sclerosis, and aging. Other human coexpression modules, including those implicated in proteostasis, are not activated in AD models but rather following other, unexpected genetic manipulations. Our results comprise a cross-species resource, highlighting transcriptional networks altered by human brain pathophysiology and identifying correspondences with mouse models for AD preclinical studies.

Identifiants

DOI: 10.1016/j.celrep.2020.107908 PMID: 32668255 PMC: PMC7428328
pubmed: 32668255
pii: S2211-1247(20)30889-5
doi: 10.1016/j.celrep.2020.107908
pmc: PMC7428328
mid: NIHMS1612517
pii:
doi:

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

107908

Subventions

Organisme : NIA NIH HHS
ID : U01 AG061357
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057339
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032990
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG061340
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046161
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG051504
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061796
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057443
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053960
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046139
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS072026
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054014
Pays : United States
Organisme : NIA NIH HHS
ID : F31 AG050357
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018023
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG017216
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046170
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS080820
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015473
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG025688
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG046174
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050631
Pays : United States
Organisme : NIA NIH HHS
ID : F31 AG067677
Pays : United States

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Références

Nucleic Acids Res. 2017 Jan 4;45(D1):D183-D189
pubmed: 27899595
Nucleic Acids Res. 2015 Jan;43(Database issue):D789-98
pubmed: 25428349
Nat Rev Neurosci. 2018 Oct;19(10):583-598
pubmed: 30194347
Cell Rep. 2018 Jan 2;22(1):269-285
pubmed: 29298427
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
J Natl Cancer Inst. 1959 Apr;22(4):719-48
pubmed: 13655060
Exp Physiol. 2013 Oct;98(10):1432-45
pubmed: 23748904
Control Clin Trials. 1986 Sep;7(3):177-88
pubmed: 3802833
BMC Syst Biol. 2012 Nov 22;6:145
pubmed: 23173819
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Nat Genet. 2013 Dec;45(12):1452-8
pubmed: 24162737
Nat Med. 2020 May;26(5):769-780
pubmed: 32284590
Sci Rep. 2015 Nov 09;5:16361
pubmed: 26549511
Neurotox Res. 2016 Feb;29(2):256-66
pubmed: 26707129
J Comp Neurol. 2016 Sep 1;524(13):2696-710
pubmed: 26917114
PLoS Comput Biol. 2015 Apr 17;11(4):e1004219
pubmed: 25885710
Ann Neurol. 2014 Apr;75(4):563-73
pubmed: 24623176
Mol Neurodegener. 2012 Nov 22;7:58
pubmed: 23173713
Nat Neurosci. 2016 Apr;19(4):623-33
pubmed: 26900923
Elife. 2016 Apr 16;5:
pubmed: 27085088
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Database (Oxford). 2010 Aug 05;2010:baq020
pubmed: 20689021
Cell Rep. 2020 Feb 11;30(6):2040-2054.e5
pubmed: 32049030
J Alzheimers Dis. 2017;57(4):1171-1183
pubmed: 28304309
PLoS Comput Biol. 2015 Nov 30;11(11):e1004574
pubmed: 26618778
Bioinformatics. 2010 Jun 15;26(12):1572-3
pubmed: 20427518
BMC Bioinformatics. 2006 Mar 20;7 Suppl 1:S7
pubmed: 16723010
Lancet Neurol. 2013 Jan;12(1):105-18
pubmed: 23237905
Cell Rep. 2019 Apr 23;27(4):1293-1306.e6
pubmed: 31018141
Genome Biol. 2014;15(12):550
pubmed: 25516281
Science. 2014 Jul 25;345(6195):455-9
pubmed: 25061210
Nature. 2019 Jun;570(7761):332-337
pubmed: 31042697
Mol Psychiatry. 2018 May;23(5):1356-1367
pubmed: 28416808
Cell Rep. 2015 Feb 3;10(4):633-44
pubmed: 25620700
Nat Neurosci. 2018 Jun;21(6):811-819
pubmed: 29802388
Science. 2014 May 2;344(6183):519-23
pubmed: 24786080
Mol Neurodegener. 2017 Dec 22;12(1):89
pubmed: 29273078
Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Dec;70(6 Pt 2):066111
pubmed: 15697438
Neuron. 2003 Oct 30;40(3):471-83
pubmed: 14642273
Acta Neuropathol. 2017 Feb;133(2):155-175
pubmed: 28025715
Bioinformatics. 2006 Apr 15;22(8):1021-3
pubmed: 16473872
Nat Neurosci. 2019 Dec;22(12):2087-2097
pubmed: 31768052
Bioinformatics. 2012 Oct 1;28(19):2520-2
pubmed: 22908215
Nat Rev Neurosci. 2007 Sep;8(9):663-72
pubmed: 17684513
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Nature. 2010 Aug 5;466(7307):761-4
pubmed: 20562860
Redox Biol. 2017 Oct;13:444-451
pubmed: 28704727
Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12
pubmed: 17245412
Mol Brain. 2016 Apr 14;9:39
pubmed: 27080240
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4530-9
pubmed: 24170860
Alzheimers Dement. 2018 Mar;14(3):352-366
pubmed: 29107053
Prog Neurobiol. 2005 Jun;76(2):77-98
pubmed: 16081203
Neuron. 2019 Feb 6;101(3):399-411.e5
pubmed: 30595332
Cold Spring Harb Perspect Med. 2012 Nov 01;2(11):
pubmed: 23002015
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Sep;80(3 Pt 2):036115
pubmed: 19905188
Genome Med. 2016 Nov 1;8(1):104
pubmed: 27799057
EMBO J. 2017 Sep 1;36(17):2473-2487
pubmed: 28768718
Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361
pubmed: 27899662
Science. 2018 Feb 9;359(6376):693-697
pubmed: 29439242
Brain Res Bull. 2016 Apr;122:1-11
pubmed: 26708939
J Neuroinflammation. 2018 Sep 6;15(1):256
pubmed: 30189875
J Neurosci. 2005 Nov 16;25(46):10637-47
pubmed: 16291936
Acta Neuropathol. 2006 Oct;112(4):389-404
pubmed: 16906426
Nat Med. 2014 Feb;20(2):130-8
pubmed: 24504409
Sci Rep. 2017 Dec 19;7(1):17762
pubmed: 29259249
PLoS One. 2010 Sep 28;5(9):
pubmed: 20927193
Nat Biotechnol. 2018 Jan;36(1):70-80
pubmed: 29227469
Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1118-23
pubmed: 18216267
Sci Data. 2018 Sep 11;5:180185
pubmed: 30204156
J Alzheimers Dis. 2018;64(s1):S161-S189
pubmed: 29865057
Cell Rep. 2013 Feb 21;3(2):301-8
pubmed: 23416048
Bioinformatics. 2007 Jul 15;23(14):1846-7
pubmed: 17496320
Alzheimers Res Ther. 2017 Sep 20;9(1):77
pubmed: 28931441
Neuron. 2014 Jul 2;83(1):11-26
pubmed: 24991952
Nature. 2016 Dec 15;540(7633):423-427
pubmed: 27919067
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nature. 2015 Feb 19;518(7539):365-9
pubmed: 25693568
Eur J Pharmacol. 2015 Jul 15;759:101-17
pubmed: 25814260
Acta Neuropathol. 2017 Aug;134(2):171-186
pubmed: 28488154
Sci Data. 2016 Oct 11;3:160089
pubmed: 27727239
Mol Neurodegener. 2017 Nov 6;12(1):82
pubmed: 29110684
Nat Methods. 2012 Jul 15;9(8):796-804
pubmed: 22796662
Mol Neurodegener. 2018 Oct 11;13(1):53
pubmed: 30326945
Nature. 2002 Apr 4;416(6880):507-11
pubmed: 11932737
Nat Genet. 2019 Mar;51(3):414-430
pubmed: 30820047
Nat Commun. 2016 Apr 21;7:11295
pubmed: 27097852
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
Nat Genet. 2019 Mar;51(3):404-413
pubmed: 30617256
Lancet. 2016 Jul 30;388(10043):505-17
pubmed: 26921134
Brain. 2015 Jul;138(Pt 7):1992-2004
pubmed: 25981962
Nucleic Acids Res. 2016 Jan 4;44(D1):D488-94
pubmed: 26481357
Nucleic Acids Res. 2015 Feb 18;43(3):1332-44
pubmed: 25583238
Neuron. 2015 Jul 1;87(1):77-94
pubmed: 26139371
Nat Med. 2004 Jul;10 Suppl:S10-7
pubmed: 15272267
Immunology. 2018 Jun;154(2):204-219
pubmed: 29513402
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Mol Syst Biol. 2014 Jul 30;10:743
pubmed: 25080494
Sci Data. 2018 Aug 07;5:180142
pubmed: 30084846
Cold Spring Harb Perspect Med. 2012 Aug 01;2(8):
pubmed: 22908189
Mol Neurodegener. 2018 Oct 4;13(1):52
pubmed: 30286791
Front Neurosci. 2016 Jan 27;10:16
pubmed: 26858593
JCI Insight. 2018 Jul 12;3(13):
pubmed: 29997299
Front Neuroendocrinol. 2014 Aug;35(3):385-403
pubmed: 24434111
BMC Bioinformatics. 2009 Nov 24;10:384
pubmed: 19930695
Behav Brain Res. 2017 Mar 30;322(Pt B):311-328
pubmed: 27155503
BMC Syst Biol. 2010 Sep 28;4:132
pubmed: 20920161
Cell. 2013 Apr 25;153(3):707-20
pubmed: 23622250
Neurobiol Aging. 2005 Mar;26(3):373-82
pubmed: 15639316
Neurobiol Dis. 2017 Jul;103:32-44
pubmed: 28363799
Nucleic Acids Res. 2014 Jan;42(Database issue):D975-9
pubmed: 24297256
Cell Syst. 2017 Jan 25;4(1):60-72.e4
pubmed: 27989508
Nat Neurosci. 2017 Aug;20(8):1162-1171
pubmed: 28671693
Brain. 2009 Feb;132(Pt 2):402-16
pubmed: 19059977
EURASIP J Bioinform Syst Biol. 2007;:79879
pubmed: 18354736

Auteurs

Ying-Wooi Wan (YW)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.

Rami Al-Ouran (R)

Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

Carl G Mangleburg (CG)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.

Thanneer M Perumal (TM)

Sage Bionetworks, Seattle, WA 98121, USA.

Tom V Lee (TV)

Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.

Katherine Allison (K)

Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.

Vivek Swarup (V)

Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.

Cory C Funk (CC)

Institute for Systems Biology, Seattle, WA 98109, USA.

Chris Gaiteri (C)

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

Mariet Allen (M)

Mayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.

Minghui Wang (M)

Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Sarah M Neuner (SM)

The Jackson Laboratory, Bar Harbor, ME 04609, USA.

Catherine C Kaczorowski (CC)

The Jackson Laboratory, Bar Harbor, ME 04609, USA.

Vivek M Philip (VM)

The Jackson Laboratory, Bar Harbor, ME 04609, USA.

Gareth R Howell (GR)

The Jackson Laboratory, Bar Harbor, ME 04609, USA.

Heidi Martini-Stoica (H)

Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.

Hui Zheng (H)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.

Hongkang Mei (H)

Neuroscience DPU, Shanghai R&D, GlaxoSmithKline, Shanghai, China.

Xiaoyan Zhong (X)

Neuroscience DPU, Shanghai R&D, GlaxoSmithKline, Shanghai, China.

Jungwoo Wren Kim (JW)

Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Valina L Dawson (VL)

Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Adrienne Helis Malvin & Diana Helis Henry Medical Research Foundations, New Orleans, LA 70130, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Ted M Dawson (TM)

Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Adrienne Helis Malvin & Diana Helis Henry Medical Research Foundations, New Orleans, LA 70130, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Ping-Chieh Pao (PC)

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Li-Huei Tsai (LH)

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Jean-Vianney Haure-Mirande (JV)

Departments of Neurology and Pediatrics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Michelle E Ehrlich (ME)

Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Departments of Neurology and Pediatrics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Paramita Chakrabarty (P)

Evelyn F. and William L. McKnight Brain Institute, Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA.

Yona Levites (Y)

Evelyn F. and William L. McKnight Brain Institute, Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA.

Xue Wang (X)

Mayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA; Mayo Clinic, Department of Health Sciences Research, Jacksonville, FL 32224, USA.

Eric B Dammer (EB)

Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.

Gyan Srivastava (G)

Data & Statistical Sciences, AbbVie, Cambridge, MA, USA.

Sumit Mukherjee (S)

Sage Bionetworks, Seattle, WA 98121, USA.

Solveig K Sieberts (SK)

Sage Bionetworks, Seattle, WA 98121, USA.

Larsson Omberg (L)

Sage Bionetworks, Seattle, WA 98121, USA.

Kristen D Dang (KD)

Sage Bionetworks, Seattle, WA 98121, USA.

James A Eddy (JA)

Sage Bionetworks, Seattle, WA 98121, USA.

Phil Snyder (P)

Sage Bionetworks, Seattle, WA 98121, USA.

Yooree Chae (Y)

Sage Bionetworks, Seattle, WA 98121, USA.

Sandeep Amberkar (S)

Sheffield Institute of Translational Neuroscience, University of Sheffield, Sheffield, S10 2HQ, UK; Molecular Oncology Lab, Cancer Research UK - Manchester Institute, The University of Manchester, Manchester, SK10 4TG, UK.

Wenbin Wei (W)

Sheffield Institute of Translational Neuroscience, University of Sheffield, Sheffield, S10 2HQ, UK; Department of Biosciences, Durham University, Durham, DH1 3LE, UK.

Winston Hide (W)

Sheffield Institute of Translational Neuroscience, University of Sheffield, Sheffield, S10 2HQ, UK; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

Christoph Preuss (C)

The Jackson Laboratory, Bar Harbor, ME 04609, USA.

Ayla Ergun (A)

Translational Genome Sciences, Biogen, Cambridge, MA, USA.

Phillip J Ebert (PJ)

Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

David C Airey (DC)

Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

Sara Mostafavi (S)

University of British Columbia, Vancouver, BC, Canada.

Lei Yu (L)

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

Hans-Ulrich Klein (HU)

Center for Translational & Computational Neuroimmunology, Department of Neurology and Taub Institute for the Study of Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA; Cell Circuits Program, Broad Institute, Cambridge, MA 02142, USA.
Full consortium author list available at http://doi.org/10.7303/syn17114455.

Gregory W Carter (GW)

The Jackson Laboratory, Bar Harbor, ME 04609, USA.

David A Collier (DA)

Eli Lilly & Company, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, UK.

Todd E Golde (TE)

Evelyn F. and William L. McKnight Brain Institute, Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA.

Allan I Levey (AI)

Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.

David A Bennett (DA)

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

Karol Estrada (K)

Translational Genome Sciences, Biogen, Cambridge, MA, USA.

T Matthew Townsend (TM)

Foundation Neuroscience Center, AbbVie, Cambridge, MA, USA.

Bin Zhang (B)

Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Eric Schadt (E)

Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Philip L De Jager (PL)

Center for Translational & Computational Neuroimmunology, Department of Neurology and Taub Institute for the Study of Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA; Cell Circuits Program, Broad Institute, Cambridge, MA 02142, USA.

Nathan D Price (ND)

Institute for Systems Biology, Seattle, WA 98109, USA.

Nilüfer Ertekin-Taner (N)

Mayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA; Mayo Clinic, Department of Neurology, Jacksonville, FL 32224, USA.

Zhandong Liu (Z)

Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: zhandonl@bcm.edu.

Joshua M Shulman (JM)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: joshua.shulman@bcm.edu.

Lara M Mangravite (LM)

Sage Bionetworks, Seattle, WA 98121, USA. Electronic address: lara.mangravite@sagebionetworks.org.

Benjamin A Logsdon (BA)

Sage Bionetworks, Seattle, WA 98121, USA. Electronic address: ben.logsdon@sagebionetworks.org.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Eucaryotes › Animaux › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Phénomènes biologiques › Spécificité d'espèce › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Meta-Analysis of the Alzheimer's Disease Human...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Meta-Analysis of the Alzheimer's Disease Human...