Ubiquitin ligase SMURF2 enhances epidermal growth factor receptor stability and tyrosine-kinase inhibitor resistance.
Amino Acid Substitution
Animals
CHO Cells
Cricetulus
Drug Resistance, Neoplasm
/ drug effects
Enzyme Stability
/ drug effects
ErbB Receptors
/ genetics
Erlotinib Hydrochloride
/ pharmacology
HEK293 Cells
Humans
Lung Neoplasms
/ drug therapy
MCF-7 Cells
Mutation, Missense
Neoplasm Proteins
/ genetics
Protein Kinase Inhibitors
/ pharmacology
Ubiquitin-Conjugating Enzymes
/ genetics
Ubiquitin-Protein Ligases
/ genetics
E3 ubiquitin ligase
Smad ubiquitination regulatory factor 2 (SMURF2)
epidermal growth factor receptor (EGFR)
protective ubiquitination
receptor regulation
tyrosine kinase inhibitor (TKI) resistance
tyrosine-protein kinase (tyrosine kinase)
ubiquitin-conjugating enzyme H5 (UBCH5)
ubiquitylation (ubiquitination)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
04 09 2020
04 09 2020
Historique:
received:
01
04
2020
revised:
10
07
2020
pubmed:
17
7
2020
medline:
28
1
2021
entrez:
17
7
2020
Statut:
ppublish
Résumé
The discovery of activating epidermal growth factor receptor (EGFR) mutations spurred the use of EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib, as the first-line treatment of lung cancers. We previously reported that differential degradation of TKI-sensitive (
Identifiants
pubmed: 32669362
pii: S0021-9258(17)49981-9
doi: 10.1074/jbc.RA120.013519
pmc: PMC7476725
doi:
Substances chimiques
Neoplasm Proteins
0
Protein Kinase Inhibitors
0
Erlotinib Hydrochloride
DA87705X9K
UBE2D1 protein, human
EC 2.3.2.23
Ubiquitin-Conjugating Enzymes
EC 2.3.2.23
SMURF2 protein, human
EC 2.3.2.26
Ubiquitin-Protein Ligases
EC 2.3.2.27
EGFR protein, human
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12661-12673Subventions
Organisme : NCI NIH HHS
ID : R01 CA131290
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA160981
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM110052
Pays : United States
Informations de copyright
© 2020 Ray et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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