Cardiovascular risk factors and accelerated cognitive decline in midlife: The CARDIA Study.

Adult Aged Aging / physiology Cardiovascular Diseases / complications Cognition / physiology Cognitive Dysfunction / complications Female Humans Hypertension / complications Male Memory / physiology Middle Aged Risk Factors

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
18 08 2020
Historique:
received: 25 07 2019
accepted: 06 03 2020
pubmed: 17 7 2020
medline: 21 10 2020
entrez: 17 7 2020
Statut: ppublish

Résumé

Increasing evidence supports an association between midlife cardiovascular risk factors (CVRFs) and risk of dementia, but less is known about whether CVRFs influence cognition in midlife. We examined the relationship between CVRFs and midlife cognitive decline. In 2,675 black and white middle-aged adults (mean age 50.2 ± 3.6 years, 57% female, 45% black), we measured CVRFs at baseline: hypertension (31%), diabetes mellitus (11%), obesity (43%), high cholesterol (9%), and current cigarette smoking (15%). We administered cognitive tests of memory, executive function, and processing speed at baseline and 5 years later. Using logistic regression, we estimated the association of CVRFs with accelerated cognitive decline (race-specific decline ≥1.5 SD from the mean change) on a composite cognitive score. Five percent (n = 143) of participants had accelerated cognitive decline over 5 years. Smoking, hypertension, and diabetes mellitus were associated with an increased likelihood of accelerated decline after multivariable adjustment (adjusted odds ratio [AOR] 1.65, 95% confidence interval [CI] 1.00-2.71; AOR 1.87, 95% CI 1.26-2.75; AOR 2.45, 95% CI 1.54-3.88, respectively), while obesity and high cholesterol were not associated with risk of decline. These results were similar when stratified by race. The likelihood of accelerated decline also increased with greater number of CVRFs (1-2 CVRFs: AOR 1.77, 95% CI 1.02-3.05; ≥3 CVRFs: AOR 2.94, 95% CI 1.64-5.28) and with Framingham Coronary Heart Disease Risk Score ≥10 (AOR 2.29, 95% CI 1.21-4.34). Midlife CVRFs, especially hypertension, diabetes mellitus, and smoking, are common and associated with accelerated cognitive decline at midlife. These results identify potential modifiable targets to prevent midlife cognitive decline and highlight the need for a life course approach to cognitive function and aging.

Identifiants

DOI: 10.1212/WNL.0000000000010078 PMID: 32669394 PMC: PMC7605504
pubmed: 32669394
pii: WNL.0000000000010078
doi: 10.1212/WNL.0000000000010078
pmc: PMC7605504
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e839-e846

Subventions

Organisme : NHLBI NIH HHS
ID : HHSN268201800003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800006I
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122658
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800005I
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063887
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800004I
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001455
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800007I
Pays : United States

Informations de copyright

© 2020 American Academy of Neurology.

Références

Biochim Biophys Acta. 2012 Mar;1822(3):340-9
pubmed: 21777675
Neurology. 2005 Jan 25;64(2):277-81
pubmed: 15668425
N Engl J Med. 2013 Dec 12;369(24):2275-7
pubmed: 24283198
Acta Neuropathol. 2010 Sep;120(3):287-96
pubmed: 20623294
Circulation. 2014 Apr 15;129(15):1560-7
pubmed: 24687777
J Am Coll Cardiol. 2017 May 9;69(18):2279-2289
pubmed: 28473132
Am J Public Health. 2008 Dec;98(12):2244-50
pubmed: 18923116
JAMA. 2017 Apr 11;317(14):1443-1450
pubmed: 28399252
Hypertension. 2016 Dec;68(6):e67-e94
pubmed: 27977393
Med Sci Sports Exerc. 2014 Aug;46(8):1570-7
pubmed: 24496119
Lancet Neurol. 2010 Jan;9(1):119-28
pubmed: 20083042
Diabetes Care. 2010 Sep;33(9):1964-9
pubmed: 20519662
Neuropsychology. 2014 Jul;28(4):653-65
pubmed: 24635711
Brain Behav Immun. 2015 Aug;48:195-204
pubmed: 25882911
JAMA. 2019 Feb 12;321(6):553-561
pubmed: 30688979
Neurology. 2013 Apr 2;80(14):1300-6
pubmed: 23547265
Nat Rev Cardiol. 2015 May;12(5):267-77
pubmed: 25583619
Circulation. 1998 May 12;97(18):1837-47
pubmed: 9603539
JAMA. 2005 Oct 12;294(14):1773-81
pubmed: 16219880
Neurobiol Aging. 2011 Jan;32(1):63-74
pubmed: 19285755
Psychol Bull. 1991 Mar;109(2):163-203
pubmed: 2034749
Obes Rev. 2008 May;9(3):204-18
pubmed: 18331422
Arch Neurol. 1999 Mar;56(3):303-8
pubmed: 10190820
JAMA. 2004 Nov 10;292(18):2237-42
pubmed: 15536110
J Am Geriatr Soc. 2010 Jul;58(7):1322-6
pubmed: 20609030
Lancet Neurol. 2011 Sep;10(9):819-28
pubmed: 21775213
Am J Geriatr Psychiatry. 2012 Mar;20(3):266-75
pubmed: 22354117
JAMA. 1995 Dec 20;274(23):1846-51
pubmed: 7500533
J Lipid Res. 1988 Nov;29(11):1535-43
pubmed: 3241128
Lancet Diabetes Endocrinol. 2014 Mar;2(3):228-35
pubmed: 24622753
Neurology. 2011 Oct 4;77(14):1351-6
pubmed: 21900628
Am J Epidemiol. 1998 Nov 1;148(9):859-68
pubmed: 9801016
Am J Epidemiol. 2007 Aug 15;166(4):367-78
pubmed: 17573335
Neurology. 2001 Jan 9;56(1):42-8
pubmed: 11148234
Am J Epidemiol. 2009 Aug 15;170(4):428-37
pubmed: 19574344
Transl Psychiatry. 2018 Jan 10;8(1):18
pubmed: 29317609
PLoS Med. 2018 Mar 13;15(3):e1002516
pubmed: 29534066
J Cardiopulm Rehabil. 1989 Nov;9(11):448-459
pubmed: 29657358
Control Clin Trials. 1987 Dec;8(4 Suppl):68S-73S
pubmed: 3440391
J Clin Epidemiol. 2005 Dec;58(12):1308-15
pubmed: 16291476
Future Cardiol. 2015;11(1):101-13
pubmed: 25606706
J Clin Epidemiol. 1988;41(11):1105-16
pubmed: 3204420
Alzheimers Dement. 2019 Jul;15(7):995-1003
pubmed: 30240574

Auteurs

Kristine Yaffe (K)

From the Departments of Psychiatry (K.Y., A.L.B.), Neurology (K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; San Francisco VA Medical Center (K.Y.); Northern California Institute Research for Research and Education (T.D.H.), San Francisco; University of Massachusetts School of Medicine (S.F.), Worchester; School of Public Health (D.R.J.), University of Minnesota, Minneapolis; School of Public Health (C.E.L.), University of Alabama at Birmingham; Northwestern University Feinberg School of Medicine (D.M.L.-J.), Chicago, IL; Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and National Heart, Lung, and Blood Institute (J.R.), Bethesda, MD. kristine.yaffe@ucsf.edu.

Amber L Bahorik (AL)

From the Departments of Psychiatry (K.Y., A.L.B.), Neurology (K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; San Francisco VA Medical Center (K.Y.); Northern California Institute Research for Research and Education (T.D.H.), San Francisco; University of Massachusetts School of Medicine (S.F.), Worchester; School of Public Health (D.R.J.), University of Minnesota, Minneapolis; School of Public Health (C.E.L.), University of Alabama at Birmingham; Northwestern University Feinberg School of Medicine (D.M.L.-J.), Chicago, IL; Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and National Heart, Lung, and Blood Institute (J.R.), Bethesda, MD.

Tina D Hoang (TD)

From the Departments of Psychiatry (K.Y., A.L.B.), Neurology (K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; San Francisco VA Medical Center (K.Y.); Northern California Institute Research for Research and Education (T.D.H.), San Francisco; University of Massachusetts School of Medicine (S.F.), Worchester; School of Public Health (D.R.J.), University of Minnesota, Minneapolis; School of Public Health (C.E.L.), University of Alabama at Birmingham; Northwestern University Feinberg School of Medicine (D.M.L.-J.), Chicago, IL; Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and National Heart, Lung, and Blood Institute (J.R.), Bethesda, MD.

Sarah Forrester (S)

From the Departments of Psychiatry (K.Y., A.L.B.), Neurology (K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; San Francisco VA Medical Center (K.Y.); Northern California Institute Research for Research and Education (T.D.H.), San Francisco; University of Massachusetts School of Medicine (S.F.), Worchester; School of Public Health (D.R.J.), University of Minnesota, Minneapolis; School of Public Health (C.E.L.), University of Alabama at Birmingham; Northwestern University Feinberg School of Medicine (D.M.L.-J.), Chicago, IL; Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and National Heart, Lung, and Blood Institute (J.R.), Bethesda, MD.

David R Jacobs (DR)

From the Departments of Psychiatry (K.Y., A.L.B.), Neurology (K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; San Francisco VA Medical Center (K.Y.); Northern California Institute Research for Research and Education (T.D.H.), San Francisco; University of Massachusetts School of Medicine (S.F.), Worchester; School of Public Health (D.R.J.), University of Minnesota, Minneapolis; School of Public Health (C.E.L.), University of Alabama at Birmingham; Northwestern University Feinberg School of Medicine (D.M.L.-J.), Chicago, IL; Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and National Heart, Lung, and Blood Institute (J.R.), Bethesda, MD.

Cora E Lewis (CE)

From the Departments of Psychiatry (K.Y., A.L.B.), Neurology (K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; San Francisco VA Medical Center (K.Y.); Northern California Institute Research for Research and Education (T.D.H.), San Francisco; University of Massachusetts School of Medicine (S.F.), Worchester; School of Public Health (D.R.J.), University of Minnesota, Minneapolis; School of Public Health (C.E.L.), University of Alabama at Birmingham; Northwestern University Feinberg School of Medicine (D.M.L.-J.), Chicago, IL; Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and National Heart, Lung, and Blood Institute (J.R.), Bethesda, MD.

Donald M Lloyd-Jones (DM)

From the Departments of Psychiatry (K.Y., A.L.B.), Neurology (K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; San Francisco VA Medical Center (K.Y.); Northern California Institute Research for Research and Education (T.D.H.), San Francisco; University of Massachusetts School of Medicine (S.F.), Worchester; School of Public Health (D.R.J.), University of Minnesota, Minneapolis; School of Public Health (C.E.L.), University of Alabama at Birmingham; Northwestern University Feinberg School of Medicine (D.M.L.-J.), Chicago, IL; Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and National Heart, Lung, and Blood Institute (J.R.), Bethesda, MD.

Stephen Sidney (S)

From the Departments of Psychiatry (K.Y., A.L.B.), Neurology (K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; San Francisco VA Medical Center (K.Y.); Northern California Institute Research for Research and Education (T.D.H.), San Francisco; University of Massachusetts School of Medicine (S.F.), Worchester; School of Public Health (D.R.J.), University of Minnesota, Minneapolis; School of Public Health (C.E.L.), University of Alabama at Birmingham; Northwestern University Feinberg School of Medicine (D.M.L.-J.), Chicago, IL; Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and National Heart, Lung, and Blood Institute (J.R.), Bethesda, MD.

Jared P Reis (JP)

From the Departments of Psychiatry (K.Y., A.L.B.), Neurology (K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; San Francisco VA Medical Center (K.Y.); Northern California Institute Research for Research and Education (T.D.H.), San Francisco; University of Massachusetts School of Medicine (S.F.), Worchester; School of Public Health (D.R.J.), University of Minnesota, Minneapolis; School of Public Health (C.E.L.), University of Alabama at Birmingham; Northwestern University Feinberg School of Medicine (D.M.L.-J.), Chicago, IL; Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and National Heart, Lung, and Blood Institute (J.R.), Bethesda, MD.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Cardiovascular risk factors and accelerated...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Cardiovascular risk factors and accelerated...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Cardiovascular risk factors and accelerated...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiovascular risk factors and accelerated...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Cardiovascular risk factors and accelerated...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Cardiovascular risk factors and accelerated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cardiovascular risk factors and accelerated...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Cardiovascular risk factors and accelerated...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Cardiovascular risk factors and accelerated...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Cardiovascular risk factors and accelerated...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Cardiovascular risk factors and accelerated...