Application of Dexmedetomidine in Cardiopulmonary Bypass Prefilling.
blood pressure level
cardiopulmonary bypass
dexmedetomidine
postoperative cognitive
priming solution
Journal
Dose-response : a publication of International Hormesis Society
ISSN: 1559-3258
Titre abrégé: Dose Response
Pays: United States
ID NLM: 101308899
Informations de publication
Date de publication:
Historique:
received:
24
03
2020
revised:
11
05
2020
accepted:
01
06
2020
entrez:
17
7
2020
pubmed:
17
7
2020
medline:
17
7
2020
Statut:
epublish
Résumé
The purpose of this study was to explore the application of dexmedetomidine (Dex) in cardiopulmonary bypass. A total of 60 patients undergoing elective cardiopulmonary bypass were divided into control (C) group and Dex group. In the Dex group, appropriate amount of Dex was added into the membrane lung prefilling solution before anesthesia induction, while those in control group were given normal saline. The levels of mean arterial pressure (MAP) and heart rate (HR) at different times were measured. The levels of cardiac troponin I (CTNI), malondialdehyde (MDA), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) at different points (T0/T1/T2/T3/T4) in both groups were measured by enzyme-linked immunosorbent assay kits. The intraoperative and postoperative levels of MAP and HR in the 2 groups were significantly lower than those preoperatively ( Dexmedetomidine has a stable effect in cardiopulmonary priming solution.
Identifiants
pubmed: 32669984
doi: 10.1177/1559325820939764
pii: 10.1177_1559325820939764
pmc: PMC7338644
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1559325820939764Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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