Potential roles of psychological and oxidative stress in insulin resistance: a cohort-based study.
Cortisol
Insulin resistance
Oxidative stress
Psychological stress
Journal
Diabetology & metabolic syndrome
ISSN: 1758-5996
Titre abrégé: Diabetol Metab Syndr
Pays: England
ID NLM: 101488958
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
02
2020
accepted:
27
06
2020
entrez:
17
7
2020
pubmed:
17
7
2020
medline:
17
7
2020
Statut:
epublish
Résumé
The present study investigated the relationships between psychological stress indices and oxidative stress marker, also when combined with emergent insulin resistance (IR), in the non-diabetic, middle-aged subjects, exposed to frequent/chronic psychological stressors. Cross-sectional data from a cohort of non-diabetic police officers (n = 234; 19F), aged 27-56 years, were used. Plasma inflammatory (CRP, TNF-α), oxidative stress (free 8-iso-prostaglandin F In the IR subjects, most biochemical variables, inflammatory markers and urine cortisol were significantly higher, as compared to the non-IR ones. Psychological stress indices were associated with plasma 8-iso-PGF Both psychological stress indices were associated with oxidative stress, but only cortisol with HOMA-IR. In the subjects exposed to frequent/chronic psychological stressors, cortisol and oxidative stress marker affected IR incidence, being statistically attenuated, though, following adjustment for metabolic syndrome, or its components.
Sections du résumé
BACKGROUND
BACKGROUND
The present study investigated the relationships between psychological stress indices and oxidative stress marker, also when combined with emergent insulin resistance (IR), in the non-diabetic, middle-aged subjects, exposed to frequent/chronic psychological stressors.
METHODS
METHODS
Cross-sectional data from a cohort of non-diabetic police officers (n = 234; 19F), aged 27-56 years, were used. Plasma inflammatory (CRP, TNF-α), oxidative stress (free 8-iso-prostaglandin F
RESULTS
RESULTS
In the IR subjects, most biochemical variables, inflammatory markers and urine cortisol were significantly higher, as compared to the non-IR ones. Psychological stress indices were associated with plasma 8-iso-PGF
CONCLUSIONS
CONCLUSIONS
Both psychological stress indices were associated with oxidative stress, but only cortisol with HOMA-IR. In the subjects exposed to frequent/chronic psychological stressors, cortisol and oxidative stress marker affected IR incidence, being statistically attenuated, though, following adjustment for metabolic syndrome, or its components.
Identifiants
pubmed: 32670417
doi: 10.1186/s13098-020-00566-8
pii: 566
pmc: PMC7346531
doi:
Types de publication
Journal Article
Langues
eng
Pagination
58Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors have no competing interests to disclose.
Références
Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E995-E1002
pubmed: 16772320
Psychoneuroendocrinology. 2017 Jun;80:56-66
pubmed: 28319849
Ann N Y Acad Sci. 2012 Aug;1264:20-35
pubmed: 22612409
Int J Occup Med Environ Health. 2012 Jun;25(2):178-84
pubmed: 22528542
J Proteome Res. 2007 Jun;6(6):2080-93
pubmed: 17474765
Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E385-92
pubmed: 18544645
Heart Fail Rev. 2016 Jan;21(1):11-23
pubmed: 26542377
Methods Enzymol. 1999;300:3-12
pubmed: 9919502
Int Arch Occup Environ Health. 2017 Nov;90(8):835-848
pubmed: 28698925
Eur J Endocrinol. 2005 Dec;153(6):837-44
pubmed: 16322389
N Engl J Med. 1998 Jan 15;338(3):171-9
pubmed: 9428819
Psychosom Med. 2018 Jan;80(1):28-33
pubmed: 28700458
Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E353-9
pubmed: 15494608
Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2776-84
pubmed: 22982460
Front Neurosci. 2015 Jan 19;8:456
pubmed: 25646076
Diabetes Care. 2009 Jul;32(7):1302-7
pubmed: 19389821
J Clin Diagn Res. 2015 Feb;9(2):BC10-4
pubmed: 25859444
Psychoneuroendocrinology. 2015 Jan;51:227-36
pubmed: 25462896
Int J Environ Health Res. 2011 Feb;21(1):62-71
pubmed: 21246433
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12157-62
pubmed: 25097261
Metab Syndr Relat Disord. 2015 May;13(4):187-91
pubmed: 25714911
J Am Coll Cardiol. 2007 Jan 30;49(4):403-14
pubmed: 17258085
J Occup Environ Med. 2010 Jun;52(6):595-602
pubmed: 20523239
Psychoneuroendocrinology. 2017 Jan;75:124-131
pubmed: 27816820
J Health Soc Behav. 1983 Dec;24(4):385-96
pubmed: 6668417
Circulation. 2009 Oct 20;120(16):1640-5
pubmed: 19805654
Int J Mol Sci. 2019 Feb 18;20(4):
pubmed: 30781611
BMC Endocr Disord. 2013 Oct 16;13:47
pubmed: 24131857
Stress. 2009 Mar;12(2):167-77
pubmed: 18850490
Eur J Clin Invest. 2012 Jan;42(1):70-8
pubmed: 21679180
Diabetes Care. 2007 Oct;30(10):2529-35
pubmed: 17586736
Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):434-9
pubmed: 12615693
Aviat Space Environ Med. 2013 Jun;84(6):592-9
pubmed: 23745287
Diabetes Metab Syndr. 2019 Jan - Feb;13(1):18-23
pubmed: 30641693
Nature. 2006 Apr 13;440(7086):944-8
pubmed: 16612386
Nature. 2006 Dec 14;444(7121):840-6
pubmed: 17167471
Ann N Y Acad Sci. 2017 Mar;1391(1):20-34
pubmed: 27750377
AAOHN J. 2011 May;59(5):221-7
pubmed: 21534494
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5
pubmed: 15574496
Diabet Med. 2013 Jan;30(1):e8-16
pubmed: 23075206
PLoS One. 2015 Aug 14;10(8):e0133750
pubmed: 26274823
Psychoneuroendocrinology. 2015 Dec;62:327-35
pubmed: 26356041
PLoS One. 2011;6(12):e28610
pubmed: 22164311
Psychoneuroendocrinology. 2013 Sep;38(9):1698-708
pubmed: 23490070
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1771-6
pubmed: 22815343
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9383-7
pubmed: 2123555