Identification of epiretinal proliferation in various retinal diseases and vitreoretinal interface disorders.
Epiretinal membrane
Epiretinal proliferation
Full-thickness macular holes
Lamellar hole-associated epiretinal proliferation
Lamellar macular holes
Macular edema
Müller glial cells
Spectral-domain optical coherence tomography
Journal
International journal of retina and vitreous
ISSN: 2056-9920
Titre abrégé: Int J Retina Vitreous
Pays: England
ID NLM: 101677897
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
04
2020
accepted:
29
06
2020
entrez:
17
7
2020
pubmed:
17
7
2020
medline:
17
7
2020
Statut:
epublish
Résumé
To describe the presence of epiretinal proliferation in eyes with various retinal and vitreoretinal interface conditions. Consecutive patients seen at the Stein Eye Institute, by one retina specialist, from December 2018 to March 2019, and demonstrating epiretinal proliferation on optical coherence tomography (OCT) were enrolled in this cross-sectional study. Included patients were divided into two groups: vitreoretinal interface pathologies group or retinal diseases group. Presence of epiretinal proliferation and its localization within the 9 macular sectors, as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS), were assessed on OCT. 77 eyes from 69 patients demonstrated epiretinal proliferation on OCT. The most frequently involved ETDRS sector was the 1-mm central subfield, followed by inner temporal and inner nasal sectors. Localization of epiretinal proliferation correlated with the presence of any retinal abnormalities in the same quadrant (r = 0.962; P < 0.0001). 31 eyes (40.3%) demonstrated symptomatic vitreoretinal interface pathologies including lamellar macular hole, full-thickness macular hole, epiretinal membrane and history of macular peeling. 46 eyes (59.7%) manifested various retinal diseases, including age-related macular degeneration, diabetic retinopathy, refractory macular edema, vein occlusion and high myopia. Epiretinal proliferation was noted in several retinal conditions and not limited only to full-thickness and lamellar macular holes. Different mechanisms affecting retinal homeostasis might trigger Müller cells dysregulation, potentially leading to abnormal retinal remodeling.
Sections du résumé
BACKGROUND
BACKGROUND
To describe the presence of epiretinal proliferation in eyes with various retinal and vitreoretinal interface conditions.
METHODS
METHODS
Consecutive patients seen at the Stein Eye Institute, by one retina specialist, from December 2018 to March 2019, and demonstrating epiretinal proliferation on optical coherence tomography (OCT) were enrolled in this cross-sectional study. Included patients were divided into two groups: vitreoretinal interface pathologies group or retinal diseases group. Presence of epiretinal proliferation and its localization within the 9 macular sectors, as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS), were assessed on OCT.
RESULTS
RESULTS
77 eyes from 69 patients demonstrated epiretinal proliferation on OCT. The most frequently involved ETDRS sector was the 1-mm central subfield, followed by inner temporal and inner nasal sectors. Localization of epiretinal proliferation correlated with the presence of any retinal abnormalities in the same quadrant (r = 0.962; P < 0.0001). 31 eyes (40.3%) demonstrated symptomatic vitreoretinal interface pathologies including lamellar macular hole, full-thickness macular hole, epiretinal membrane and history of macular peeling. 46 eyes (59.7%) manifested various retinal diseases, including age-related macular degeneration, diabetic retinopathy, refractory macular edema, vein occlusion and high myopia.
CONCLUSIONS
CONCLUSIONS
Epiretinal proliferation was noted in several retinal conditions and not limited only to full-thickness and lamellar macular holes. Different mechanisms affecting retinal homeostasis might trigger Müller cells dysregulation, potentially leading to abnormal retinal remodeling.
Identifiants
pubmed: 32670614
doi: 10.1186/s40942-020-00233-0
pii: 233
pmc: PMC7350739
doi:
Types de publication
Journal Article
Langues
eng
Pagination
31Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsJean-Pierre Hubschman: Alcon (C), Allergan (C), Bausch and Lomb (C), Novartis (C), Carl Zeiss Meditec (C); SriniVas R. Sadda: Amgen (C), Allergan (C), Carl Zeiss Meditec (F), CenterVue (C), Genentech (C), Heidelberg engineering (C,F), 4DMT (C), Novartis (C), Optos (C), Oxurion (C), Samsung Biopses (C). The following authors have no financial disclosures: Ismael Chehaibou; Moritz Pettenkofer; Andrea Govetto; Gilad Rabina.
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