Inositols and metabolic disorders: From farm to bedside.
Diet
Food supplement
Inositol
Lipids
Metabolism
Microbiota
Ovary
Type 2 diabetes
Journal
Journal of traditional and complementary medicine
ISSN: 2225-4110
Titre abrégé: J Tradit Complement Med
Pays: Netherlands
ID NLM: 101605474
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
15
12
2019
revised:
19
03
2020
accepted:
20
03
2020
entrez:
17
7
2020
pubmed:
17
7
2020
medline:
17
7
2020
Statut:
epublish
Résumé
Inositol and its derivates are catching interest in metabolism since taking part in several physiological processes, including endocrine modulation. Through several mechanisms mostly mediated by insulin signaling, these compounds regulate the activities of several hormones and are essential in oocytes maturation. It is interesting to point out the contribution of an inositol deficiency in the development of several diseases, mainly in the metabolic and endocrine setting. Inositols derive from both diet and endogenous production; among causes of inositol deficiency reduced dietary intake, increased catabolism and/or excretion, decreased biosynthesis, inhibition of gut and cellular uptake and altered microbiota could be considered. Mounting direct and indirect evidence suggests that the two main isoforms (Myo-inositol-inositol, D-chiro-inositol) are implied in glycemic and lipidic metabolism and supplementation yield a beneficial effect on these parameters without hazards for health. Moreover, they have a role in polycystic ovary syndrome, acting as insulin-sensitizing agents and free radical scavengers, helping to regulate metabolism and promoting ovulation. The aim of this narrative review is to discuss the role of inositols in metabolic function disorders paying attention to whether these compounds could be efficacious and safe as a therapeutic agent with a focus on dietary intake and the role of gut microbiota.
Identifiants
pubmed: 32670820
doi: 10.1016/j.jtcme.2020.03.005
pii: S2225-4110(19)31266-0
pmc: PMC7340869
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
252-259Informations de copyright
© 2020 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.
Déclaration de conflit d'intérêts
The Authors declare that there is no financial/personal interest or belief that could affect their objectivity.
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