Resistance-Associated Mutations in Chronic Lymphocytic Leukemia Patients Treated With Novel Agents.
CLL
genetic aberrations
resistance-associated mutations
targeted therapy
treatment resistance
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
03
2020
accepted:
06
05
2020
entrez:
17
7
2020
pubmed:
17
7
2020
medline:
17
7
2020
Statut:
epublish
Résumé
Inhibitors of B-cell receptor signaling, ibrutinib and idelalisib, and BCL-2 antagonist, venetoclax, have become the mainstay of treatment for chronic lymphocytic leukemia (CLL). Despite significant efficacy in most CLL patients, some patients develop resistance to these agents and progress on these drugs. We provide a state-of-the-art overview of the acquired resistance to novel agents. In 80% of patients with ibrutinib failure, acquired mutations in
Identifiants
pubmed: 32670873
doi: 10.3389/fonc.2020.00894
pmc: PMC7330112
doi:
Types de publication
Systematic Review
Langues
eng
Pagination
894Informations de copyright
Copyright © 2020 Sedlarikova, Petrackova, Papajik, Turcsanyi and Kriegova.
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